Abstract
The position and properties of the mesangial cell confer a major role for these cells in the regulation of renal function (1,2). Mesangial cells reside in the intercapillary space of the glomerulus and are embedded in an extracellular matrix. The interstitial region is unique in that entry of substances from the capillary lumen to the intercapillary space occurs without crossing a capillary basement membrane, the area is therefore well suited for a sieving function.
Keywords
- Mesangial Cell
- Human Mesangial Cell
- Mesangial Cell Proliferation
- Capillary Basement Membrane
- Mesangial Proliferative Glomerulonephritis
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
Mene, P., M. S. Simonson, and M. J. Dunn. 1989. Physiology of the mesangial cell. Physiol. Rev. 69:1347–1424.
Sterzel, R.B and D.H. Lovett. 1990. Interactions of inflammatory and glomerular cells in the response to glomerular injury. In Contemporary Issues in Nephrology. B.M. Brenner, J.H. Stein, and C.B. Wilson, editors. Churchill Livingstone, 137–173.
Le, J. and J. Vilcek. 1989. Interleukin 6: Multifunctional cytokine regulating immune reactions and the acute phase protein response. Lab. Invest. 61:588–602.
Suematsu, S., T. Matsuda, K. Aozasa, S. Akira, N. Nakano, S. Ohno, J.I. Miyazaki, K.I. Yamamura, T. Hirano, and T. Kishimoto. 1989. IgG1 plasmacytosis in interleukin 6 transgenic mice. Proc. Natl. Acad. Sci. USA 86:7547–7551.
Horii, Y., A. Muraguchi, M. Iwano, T. Matsuda, T. Hirayama, H. Yamada, Y. Fujii, K. Dohi, H. Ishikawa, Y. Ohmoto, K. Yoshizaki, T. Hirano, and T. Kishimoto. 1989. Involvement of IL-6 in mesangial proliferative glomerulonephritis. J. Immunol. 143:3949–3955.
Ruef, C., K. Budde, J. Lacey, W. Northemann, M. Bauman, R.B. Sterzel, and D.L. Coleman. 1990. Interleukin 6 is an autocrine growth factor for mesangial cells. Kidney Int. 38:249–257.
Yoshimura, T., K. Matsushima, S. Tanaka, E.A. Robinson, E. Appella, J.J. Oppenheim, and E.J. Leonard. 1987. Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc. Natl. Acad. Sci. USA 84:9233–9237.
Walz, A., P. Peveri, H. Aschauer, and M. Baggiolini. 1987. Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes. Biochem. Biophys. Res. Commun. 149:755–761.
Schröder, J.-M., U. Mrowietz, E. Morita, and E. Christophers. 1987. Purification and partial biochemical characterization of a human monocyte-derived, neutrophil activating peptide that lacks interleukin 1 activity. J. Immunol. 139:3474–3483.
Van Damme, J., J. Van Beeumen, G. Opdenakker, and A. Billiau. 1988. A novel, NH2-terminal sequence-characterized human monokine possessing neutrophil chemotactic, skin-reactive, and granulocytosis-promoting activity. J. Exp. Med. 167:1364–1376.
Westwick, J., S.W. Li, and R.D.R. Camp. 1989. Novel neutrophil-stimulating peptides. Immunol. Today 10:146–147.
Bacon, K.B., J. Westwick, and R.D.R. Camp. 1989. Potent and specific inhibition of IL-8, IL-1α- and IL- 1β-induced in vitro human lymphocyte migration by calcium channel antagonists. Biochem. Biophys. Res. Commun. 165:349–354.
Larsen, C.G., A.O. Anderson, A. Apella, J.J. Oppenheim, and K. Matsushima. 1989. The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes. Science 243:1464–1466.
Baggiolini, M., A. Walz, and S.L. Kunkel. 1990. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates human neutrophils. J. Clin. Invest. 84:1045–1050.
Watson, M.L., G.P. Lewis, and J. Westwick. 1988. Neutrophil stimulation by recombinant cytokines and a factor from IL-1-treated human synovial cell cultures. Immunology 65:567–572.
Becker, C.G. 1972. Demonstration of actomyosin in the mesangial cells of the renal glomerulus. Am. J. Pathol. 66:97–110.
Eisenberg, S.P., R.J. Evans, W.P. Arend, E. Verderber, M.T. Brewer, C.H. Hannum, and R.C. Thompson. 1990. Primary structure and functional expression from complementary DNA of a human interleukin 1 antagonist. Nature 343:341–346.
Arend, W.P., H.G. Welgus, R.C. Thompson, and S.P. Eisenberg. 1990. Biological properties of recombinant human monocyte derived interleukin 1 receptor antagonist. J. Clin. Invest. 85:1694–1697.
Striker, G.E. and L.J. Striker. 1985. Glomerular cell culture. Lab. Invest. 53:2:122–122.
Sterzel, R.B., D.H. Lovett, H.G. Foellmer, M.C. Perfetto, D. Biemesderfer, and M. Kashgarian. 1986. Mesangial cell hillocks: Nodular foci of exaggerated growth of cells and matrix in prolonged culture. Am. J. Pathol. 125:130–140.
Ceska, M., F. Effenberger, P. Peichi, and E. Pursch. 1989. Purification and characterisation of monoclonal andpolyclonal antibodies to neutrophil activation peptide (NAP-1). The developement of highly sensitive ELISA methods for the determination of NAP-1 and anti-NAP-1 antibodies, cytokine 1:136–136.
Streiter, R.M., S.L. Kunkel, H.J. Showeil, D.G. Remick, S.H. Phan, P.A. Ward, and R.M. Marks. 1989. Endothelial cell gene expression of a neutrophil chemotactic factor by TNFα, LPS and IL- 1β. Science 243:1467–1469.
Lovett, D.H., K. Resch, and D. Gemsa. 1987. Interleukin-1 and the glomerular mesangium. Am. J. Pathol. 129:543–551.
Baud, L., J.-P. Oudinet, M. Bens, L. Noe, M.-N. Peraldi, E. Rondeau, J. Etienne, and R. Ardaillou. 1989. Production of tumor necrosis factor by rat mesangial cells in response to bacterial lipopolysaccharide. Kidney Int. 35:1111–1118.
Granstein, R.D., R. Margolis, S.B. Mizel, and D.N. Sauder. 1986. In vivo inflammatory activity of epidermal cell-derived thymocyte activating factor and recombinant interleukin 1 in the mouse. J. Clin. Invest. 77:1020–1027.
Watson, M.L., G.P. Lewis, and J. Westwick. 1989. Increased vascular permeability and polymorphonuclear leukocyte accumulation in vivo in response to recombinant cytokines and a factor produced by interleukin 1-treated human synovial cell cultures. Br. J. Exp. Pathol. 70:93–101.
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© 1991 Plenum Press, New York
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Brown, Z., Fairbanks, L., Strieter, R.M., Neild, G.H., Kunkel, S.L., Westwick, J. (1991). Human Mesangial Cell-Derived Interleukin 8 and Interleukin 6: Modulation by an Interleukin 1 Receptor Antagonist. In: Westwick, J., Lindley, I.J.D., Kunkel, S.L. (eds) Chemotactic Cytokines. Advances in Experimental Medicine and Biology, vol 305. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6009-4_16
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DOI: https://doi.org/10.1007/978-1-4684-6009-4_16
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