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Chemotactic Cytokines pp 119–126Cite as

Interleukin-8 —A Mediator of Inflammatory Lung Disease?

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 305))

Abstract

Chronic inflammation is a feature of the airways of patients exhibiting lung diseases such as asthma, sarcoidosis and bronchitis. This has been recognised from autopsy studies of asthmatic airways (1) and has also been shown to be evident in the airways of asthmatics who have mild asthma (2) or are asymptomatic (3). Bronchial airway hyperreactivity (BHR) to a wide range of pharmacological and physical agents is one of the most characteristic features of asthmatic airways. It is known that intensification of BHR follows antigen challenge in atopic asthmatics (4) and it has been widely presumed that inflammatory events during late-onset reactions may determine the changes in airway reactivity (5).

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Hunterian Institute, Royal College of Surgeons, Lincolns Inn Fields, London, WC2A 3PN, UK

    Diana Smith, Lisa Burrows & John Westwick

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  1. Diana Smith
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  2. Lisa Burrows
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  3. John Westwick
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Editor information

Editors and Affiliations

  1. The University of Bath, Avon, UK

    J. Westwick

  2. Sandoz Research Institute, Vienna, Austria

    I. J. D. Lindley

  3. University of Michigan, Ann Arbor, Michigan, USA

    S. L. Kunkel

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© 1991 Plenum Press, New York

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Smith, D., Burrows, L., Westwick, J. (1991). Interleukin-8 —A Mediator of Inflammatory Lung Disease?. In: Westwick, J., Lindley, I.J.D., Kunkel, S.L. (eds) Chemotactic Cytokines. Advances in Experimental Medicine and Biology, vol 305. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6009-4_14

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  • DOI: https://doi.org/10.1007/978-1-4684-6009-4_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-6011-7

  • Online ISBN: 978-1-4684-6009-4

  • eBook Packages: Springer Book Archive

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