Abstract
Psoriasis is a skin disease characterized by epidermal hyperproliferation as well as an inflammatory cell infiltrate in the epidermis predominantly consisting of polymorphonuclear leukocytes (PMN) (1). The absence of bacteria as the cause of PMN infiltration led to the hypothesis that endogenous chemoattractants located in the epidermal cell layer of psoriatic plaques may attract PMN into the inflammatory focus.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Braun-Falco, O., and E. Christophers. 1974. Structural aspects of initial psoriatic lesions. Arch. Derm. Forsch. 251: 95–110.
Tagami, H., and S. Ofuji. 1977. Characterization of a leukotactic factor derived form psoriatic scale. Br. J. Dermatol. 97: 509–518.
Brain, S.D., R.D.R. Camp, P.M. Dowd, M.W. Greaves, A.K. Black, A.I. Mallet, and P.M. Woollard. 1983. Leukotriene B4 and monohydroxy eicosatetraenoic acid-like material are released in biologically active amounts from the lesional skin of patients with psoriasis. Br. J. Dermatol. 83: 313–317.
Hammarström, S., M. Hamberg, B. Samuelsson, E.A. Duell, M. Stawiski, and J.J. Vorhees. 1975. Increased concentrations of nonsterified arachidonic acid, 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2 and prostaglandin F2, in epidermis of psoriasis. Proc. Natl. Acad. Sci. USA 72: 5130–5134.
Mallet, A.I., F.M. Cunningham, and R. Daniel. 1984. Rapid isocratic high-performance liquid chromatographic purification of platelet activating factor (PAF) and lyso-PAF from human skin. J. Chromatogr. 309: 160–164.
Fernandez, H.N., and T.E. Hugli. 1976. Partial characterization of human C5a anaphylatoxin. I. Chemical Description of the carbohydrate and polypeptide portion of human C5a. J. Immunol. 117: 1688–1693.
Tagami, H., Y. Kitano, S. Suehisa, T. Iku, and M. Yamada. 1982. Psoriatic leukotactic factor. Further physicochemical characterization and effect on the epidermal cells. Arch. Dermatol. Res. 272: 201–213.
Schröder, J.-M., and E. Christophers. 1986. Identification of C5ades and an Anionic Neutrophil-Activating Peptide (ANAP) in Psoriatic Scales. J. Invest. Dermatol. 87: 53–58.
Bokisch , V.A., and H.J. Müller-Eberhard. 1970. Anaphylatoxin inactivator of human plasma; its isolation and characterization as a carboxy-peptidase. J. Clin. Invest. 49: 2477–2436.
Schröder, J.-M., U. Mrowietz, E. Morita, and E. Christophers. 1987. Purification and partial biochemical characterization of a human monocyte-derived neutrophil-activating peptide that lacks Interleukin 1 activity. J. Immunol. 139: 3474–3483.
Yoshimura, T., K. Matsushima, S. Tanaka, E.E. Robinson, E. Appella, J. J.Oppenheim and E. J. Leonard. 1987. Purification of a human monocyte-derived neutrophil chemotactic factor that shares sequence homology with other host defense cytokines. Proc. Natl. Acad. Sci. USA 84: 9233–9237.
Walz, A., P. Peveri, H. Aschauer, and M. Baggiolini. 1987. Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes. Biochem. Biophys. Res. Commun. 149: 755–761.
Van Damme, J., J. Van Beeumen, G. Opdenakker, and A. Billiau. 1988. NH2-terminal sequence-characterized human monokine possessing neutrophil chemotactic, skin-reactive and granulocytosis-promoting activity. J. Exp. Med. 167: 1364–1376.
Gronhoj-Larsen, C., A. O. Anderson, E. Appella, J.J. Oppenheim, and K. Matsushima. 1989. The Neutrophil-Activating Protein (NAP-1) Is Also Chemotactic for T Lymphocytes. Science 243: 1464–1466.
Westwick, J., S.W. Li, and R.D. Camp. 1989. Novel neutrophil stimulating peptides. Immunology Today 10: 146–147.
Sauder, D. N., Mounessa, N.L., S.I. Katz, C.A. Dinarello, and J.I. Gallin. 1984. Chemotactic cytokines: the role of leukotactic pyrogen and epidermal cell thymocyte activating factor in neutrophil Chemotaxis. J. Immunol. 132: 828–832.
Luger, T.A., J. A. Charon, M. Colot, M. Micksche, and J.J. Oppenheim. 1983. Chemotactic properties of partially purified human epidermal cell-derived thymocyte-activating factor (ETAF) for polymorphonuclear and mononuclear cells. J. Immunol. 131: 816–820.
Georgilis, K., C. Schäfer, C.A. Dinarello, and M.S. Klempner. 1987. Human recombinant interleukin 1β has no effect on intracellular calcium or on functional responses of human neutrophils. J. Immunol. 139: 3403–3407.
Schröder, J.-M., J. Young, H. Gregory, and E. Christophers. 1990. Neutrophil Activating Proteins in Psoriasis. Submitted.
Richmond, A., E. Balentien, H.G. Thomas, G. Flaggs, D.E. Barton, J. Spiess, R. Bardoni, U. Francke, and R. Derynck. 1988. Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to β-thromboglobulin. EMBO J. 7: 2025–2033.
Kähler, S., E. Christophers, and J.-M. Schröder. 1988. Plasma lactoferrin reflects neutrophil activation in psoriasis. Br. J. Dermatol. 119: 289–293.
Schröder, J.-M., and E. Christophers. 1989. Secretion of novel and homologues neutrophil activating peptides by LPS-stimulated human endothelial cells. J. Immunol. 142: 244–251.
Schröder, J.-M., M. Sticherling, H.-H. Henneicke, W.C. Preissner, and E. Christophers. 1990. IL-1α or TNFα stimulate release of three IL-8-related neutrophil chemotactic proteins in human dermal fibroblasts. J. Immunol. 144: 2223–2232.
Barker, J.N. W.N., V. Sana, R.S. Mitra, V.M. Dixit, and B.J. Nickoloff. 1990. Marked Synergism between Tumor Necrosis Factor α and Interferon in Regulation of Keratinocyte-derived Adhesion Molecules and Chemotactic Factors. J. Clin. Invest. 85: 605–608.
Barker, J.N. W.N., C.E.M. Griffiths, R.S. Mitra, J. T. Elder, V. Dixit, S.Kunkel, and B J. Nickoloff. 1990. Keratinocyte-Derived Interleukin-8 (IL-8): Regulation by TPA and Urushiol and Detection in Inflamed Skin. J. Invest. Dermatol. In press.
Matsushima, K. and J.J. Oppenheim. 1989. Interleukin 8 and MCAF: Novel Inflammatory Cytokines Inducible by IL 1 and TNF. Cytokine 1: 2–13.
Baggiolini, M., A. Walz, and S.L. Kunkel. 1989. Neutrophil-activating Peptide-1/Interleukin 8, a Novel Cytokine That Activates Neutrophils. J. Clin. Invest. 84: 1045–1049.
Schröder, J.-M., N. Persoon, and E. Christophers. 1990. Lipopolysaccharide-stimulated human monocytes secrete apart from NAP-1/IL-8 a second neutrophil-activating protein: NH2-terminal amino acid sequence-identity with melanoma growth stimulatory activity (MGSA/gro). J. Exp. Med. 171: 1091–1100.
Golds, E.E., P.P. Mason, and P. Nyirkos. 1990. Inflammatory cytokines induce synthesis and secretion of gro protein and a neutrophil chemotactic factor but not β2-microglobulin in human synovial cells and fibroblasts. Biochem. J. 259: 585–588.
Schröder, J.-M. 1989. The monocyte-derived neutrophil activating peptide (NAP/Interleukin 8) stimulates human neutrophil arachidonate 5-lipoxygenase but not release of cellular arachidonate. J. Exp. Med. 170: 847–863.
Krueger, G, C. Jörgensen, C. Miller, J.-M. Schröder, M. Sticherling, and E. Christophers. 1990. Effects of IL-8 on epidermal proliferation. J. Invest. Dermatol. 94: 545 (abstract).
Schägger, H., and G. von Jagow. 1987. Tricine-Sodium, Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis for the Separation of Proteins in the Range from 1 to 100 kDa. Anal. Biochem. 166: 368–377.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Plenum Press, New York
About this chapter
Cite this chapter
Schröder, JM. (1991). Biochemical and Biological Characterization of NAP-1/ IL-8-Related Cytokines in Lesional Psoriatic Scale. In: Westwick, J., Lindley, I.J.D., Kunkel, S.L. (eds) Chemotactic Cytokines. Advances in Experimental Medicine and Biology, vol 305. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6009-4_12
Download citation
DOI: https://doi.org/10.1007/978-1-4684-6009-4_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-6011-7
Online ISBN: 978-1-4684-6009-4
eBook Packages: Springer Book Archive