An Analysis of Length-Dependent Active Stiffness in Smooth Muscle Strips

  • Richard A. Meiss
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 304)


The measured stiffness of contracting smooth muscle is strongly dependent on the level of developed force. This force-dependent stiffness is a consequence of contractile activity, and it is possible that a portion of it represents the stiffness of the population of attached crossbridges. The relationship between force and stiffness is sensitive to the particular stage of the contraction-and-relaxation cycle (Meiss, 1978), to specific external mechanical constraints imposed on the muscle (Meiss, 1987), and to the length of the muscle when the stiffness is measured (Meiss, 1978; Meiss, 1990). The character of the length-dependent stiffness relationship depends on the mechanical mode of contraction, and interpretation of these effects rests on assumptions regarding how the process of stiffness measurement interacts with changing tissue dimensions. The purpose of this paper is to characterize the difference between the length-dependent stiffness measured in isotonic and isometric contractions. Possible reasons for the differences will be considered, and a tentative model to account for the isotonic length-dependence of stiffness will be proposed.


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  1. Gabella, G., 1984, Structural apparatus for force transmission in smooth muscle, Physiol. Rev., 64: 455.PubMedGoogle Scholar
  2. Gabella, G., 1976, Quantitative morphological study of smooth muscle cells of the guinea pig taenia coli. Structural changes in smooth muscles during isotonic contraction, Cell Tissue Res., 170: 161.PubMedGoogle Scholar
  3. Meiss, R. A., 1990, The effect of tissue properties on smooth muscle mechanics, in: “Frontiers in Smooth Muscle Research”, N. Sperelakis and J. D. Wood, eds., Wiley-Liss, New York, p. 435.Google Scholar
  4. Meiss, R. A., 1978, Dynamic stiffness of rabbit mesotubarium smooth muscle: Effect of isometric length, Am. J. Physiol., 3: C14.Google Scholar
  5. Meiss, R. A., 1987, Stiffness of active smooth muscle during forced elongation, Am. J. Physiol., 22: C484.Google Scholar
  6. Mullins, G. L. and Gutheroth, W. G., 1965, A collagen net hypothesis for force transference of smooth muscle, Nature, 206: 592.PubMedCrossRefGoogle Scholar
  7. Warshaw, D. M., McBride, W. J., and Work, S. S., 1987, Corkscrew-like shortening in single smooth muscle cells, Science, 236: 1457.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Richard A. Meiss
    • 1
  1. 1.Indiana University School of MedicineIndianapolisUSA

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