Can Different Four-State Crossbridge Models Explain Latch and the Energetics of Vascular Smooth Muscle?
Ca2+ binding to troponin and the resulting thin filament conformational change acts as a switch in striated muscle that enables crossbridges to bind to actin and cycle (Rüegg, 1986). This allosteric “Ca2+-switch” mechanism generates only two primary crossbridge states: free and attached (Huxley, 1957).
KeywordsMyosin Light Chain Kinase Regulatory Light Chain Detachment Rate Myosin Light Chain Phosphatase Myosin Phosphorylation
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