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Can Different Four-State Crossbridge Models Explain Latch and the Energetics of Vascular Smooth Muscle?

  • Chi-Ming Hai
  • Christopher M. Rembold
  • Richard A. Murphy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 304)

Abstract

Ca2+ binding to troponin and the resulting thin filament conformational change acts as a switch in striated muscle that enables crossbridges to bind to actin and cycle (Rüegg, 1986). This allosteric “Ca2+-switch” mechanism generates only two primary crossbridge states: free and attached (Huxley, 1957).

Keywords

Myosin Light Chain Kinase Regulatory Light Chain Detachment Rate Myosin Light Chain Phosphatase Myosin Phosphorylation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Chi-Ming Hai
    • 1
  • Christopher M. Rembold
    • 2
    • 3
  • Richard A. Murphy
    • 2
  1. 1.Section of Physiology and BiophysicsBrown UniversityProvidenceUSA
  2. 2.Department of PhysiologyUniversity of Virginia Health Sciences CenterCharlottesvilleUSA
  3. 3.Department of Internal Medicine (Cardiology)University of Virginia Health Sciences CenterCharlottesvilleUSA

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