Skip to main content
SpringerLink
Log in

Genetic Instability and Tumor Development

  • Chapter
Boundaries between Promotion and Progression during Carcinogenesis

Part of the book series: Basic Life Sciences ((BLSC,volume 57))

Abstract

This paper will discuss in very general terms, with relatively few data, the issue of genetic instability and what role it may play in the process of tumor progression. It will include both comments on tumor progression in general and on instability from a cytogenetic approach.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. L. Foulds, Tumor progression, Cancer Res. 17:355–356 (1957).

    PubMed  CAS  Google Scholar 

  2. J. Cairns, Mutation, selection and the natural history of cancer, Nature 255:197–200 (1975).

    Article  PubMed  CAS  Google Scholar 

  3. P. Nowell, The clonal evolution of tumor cell populations, Science 194:23–28 (1976).

    Article  PubMed  CAS  Google Scholar 

  4. G. Klein, Lymphoma development in mice and humans: diversity of initiation is followed by convergent cytogenetic evolution, Proc. Natl. Acad. Sci. USA 76:2442–2446 (1979).

    Article  PubMed  CAS  Google Scholar 

  5. P. Fialkow, Clonal origin of human tumors, Annu. Rev. Med. 30:135–143 (1979).

    Article  PubMed  CAS  Google Scholar 

  6. A. Arnold, J. Cossman, A. Bakhshi, et al., Immunoglobulin gene rearrangements as unique clonal markers in human lymphoid neoplasms, N. Engl. J. Med. 309:1593–1599 (1983).

    Article  PubMed  CAS  Google Scholar 

  7. P. C. Nowell, C. M. Croce, Chromosomes, genes, and cancer, Am. J. Pathol. 125:8–15 (1986).

    Google Scholar 

  8. J. L. Biedler, P. W. Malera, and B. A. Spengler, Chromosome abnormalities and gene amplification: comparison of antifolate-resistant and human neuroblastoma cell systems, in: J. D. Rowley and J. B. Ultmann, eds., “Chromosomes and Cancer: From Molecules to Man”, Academic Press, New York (1983).

    Google Scholar 

  9. K. Alitalo and M. Schwab, Oncogene amplification in tumor cells, Adv. Cancer Res. 47:235–259 (1986).

    Article  PubMed  CAS  Google Scholar 

  10. H. Koprowski, M. Herlyn, G. Balaban, et al., Expression of the receptor for epidermal growth factor correlates with increased dosage of chromosome 7 in malignant melanoma, Somatic Cell Molec. Genet. 1:297–302 (1985).

    Article  Google Scholar 

  11. S. H. Friend, T. P. Dryja, and R. A. Weinberg, Oncogenes and tumor-suppressing genes, N. Engl. J. Med. 318:618–622 (1988).

    Article  PubMed  CAS  Google Scholar 

  12. M. F. Hansen and W. K. Cavenee, Tumor suppressors: recessive mutations that lead to cancer, Cell 53:172–173 (1988).

    Article  CAS  Google Scholar 

  13. G. Klein and E. Klein, Evolution of tumors and the impact of molecular oncology, Nature 315:190–195 (1985).

    Article  PubMed  CAS  Google Scholar 

  14. J. M. Bishop, The molecular genetics of cancer, Science 235:305–311 (1987).

    Article  PubMed  CAS  Google Scholar 

  15. L. E. Babiss, S. G. Zimmer, and P. D. Fisher, Reversibility of progression of the transformed phenotype in Ad5-transformed rat embryo cells, Science 228:1099–1101 (1985).

    Article  PubMed  CAS  Google Scholar 

  16. G. Nicolson, and L. Milas, eds., “Cancer Invasion and Metastasis: Biologic and Therapeutic Aspects,” Raven Press, New York (1984).

    Google Scholar 

  17. K. Lapis, L. Liotta, and A. Rabson, eds., “Biochemistry and Molecular Genetics of Cancer Metastasis,” Martinus Nijhoff, The Hague (1986).

    Google Scholar 

  18. R. Muschel and L. A. Liotta, Role of oncogenes in metastases, Carcinogenesis 9:705–710 (1988).

    Article  PubMed  CAS  Google Scholar 

  19. G. L. Nicolson, Tumor cell instability, diversification, and progression to the metastatic phenotype: From oncogene to oncofetal expression, Cancer Res. 47:1473–1487 (1987).

    PubMed  CAS  Google Scholar 

  20. J. P. G. Volpe, Genetic instability of cancer: Why a metastatic tumor is unstable and a benign tumor is stable, Cancer Genet. Cytogenet. 34:125–134 (1988).

    Article  PubMed  CAS  Google Scholar 

  21. S. Heim, N. Mandahl, and F. Mitelman, Genetic convergence and divergence in tumor progression, Cancer Res. 48:5911–5916 (1988).

    PubMed  CAS  Google Scholar 

  22. J. J. Yunis, The chromosomal basis of human neoplasia, Science 221:227–236 (1983).

    Article  PubMed  CAS  Google Scholar 

  23. J. D. Rowley, Biological implications of consistent chromosome rearrangements in leukemia and lymphoma, Cancer Res. 44:3159–3168 (1984).

    PubMed  CAS  Google Scholar 

  24. J. Groffen, J. R. Stephenson, N. Heistercamp, et al., Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22, Cell 36:93–99 (1984).

    Article  PubMed  CAS  Google Scholar 

  25. E. Shtivelman, B. Lifshitz, R. P. Gale, et al., Fused transcript of abl and bcr genes in chronic myelogenous leukaemia, Nature 315:550–554 (1985).

    Article  PubMed  CAS  Google Scholar 

  26. S. S. Clark, J. McLaughlin, M. Timmons, et al., Expression of a distinctive BCR-ABL oncogene in Ph1-positive acute lymphocytic leukemia (ALL), Science 239:775–777 (1988).

    Article  PubMed  CAS  Google Scholar 

  27. J. D. Rowley, Ph-positive leukaemia, including chronic myelogenous leukaemia, Clin. Haematol. 9:55–86 (1980).

    PubMed  CAS  Google Scholar 

  28. P. C. Nowell, L. Moreau, P. Growney, et al., Karyotypic stability in chronic B cell leukemia, Cancer Genet. Cytogenet. 33:155–160 (1988).

    Article  PubMed  CAS  Google Scholar 

  29. P. Nowell, J. Finan, D. Glover, et al., Cytogenetic evidence for the clonal nature of Richter’s syndrome, Blood 58:183–186 (1981).

    PubMed  CAS  Google Scholar 

  30. P. C. Nowell, L. Jackson, A. Weiss, et al., Ph-positive chronic myelogenous leukemia followed for 27 years, Cancer Genet. Cytogenet. 34:57–61 (1988).

    Article  PubMed  CAS  Google Scholar 

  31. C. M. Croce and P. C. Nowell, Molecular basis of human B cell neoplasia, Blood 65:1–7 (1985).

    PubMed  CAS  Google Scholar 

  32. C. E. Gauwerky, J. Hoxie, P. C. Nowell, et al., Pre-B-cell leukemia with a t(8;14) and a t(14;18) translocation is preceded by follicular lymphoma, Oncogene 2:431–435 (1988).

    PubMed  CAS  Google Scholar 

  33. D. de Jong, B. M. H. Voetdijk, G. C. Beverstock, et al., Activation of the c-myc oncogene in a precursor-B-cell blast crisis of follicular lymphoma, presenting as composite lymphoma, N. Engl. J. Med. 318:1373–1378 (1988).

    Article  PubMed  Google Scholar 

  34. P. Leder, J. Battey, G. Lenoir, et al., Translocations among antibody genes in human cancer, Science 222:765–770 (1983).

    Article  PubMed  CAS  Google Scholar 

  35. J. J. Yunis, G. Frizzera, M. M. Oken, et al., Multiple recurrent genomic defects in follicular lymphoma: A possible model for cancer, N. Engl. J. Med. 316:79–84 (1987).

    Article  PubMed  CAS  Google Scholar 

  36. M. Isobe, G. Russo, F. G. Haluska, et al., Cloning of the gene encoding the delta subunit of the human T-cell receptor reveals its physical organization within the alpha-subunit locus and its involvement in chromosome translocations in T-cell malignancy, Proc. Natl. Acad. Sci. USA 85:3933–3937 (1988).

    Article  PubMed  CAS  Google Scholar 

  37. F. Hecht, R. Morgan, B. K.-M. Hecht, et al., Common region on chromosome 14 in T-cell leukemia and lymphoma, Science 226:1445–1446 (1984).

    Article  PubMed  CAS  Google Scholar 

  38. G. Russo, M. Isobe, L. Pegoraro, et al., Molecular analysis of a t(7;14) (q35;q32) chromosome translocation in a T cell leukemia of a patient with ataxia telangiectasia, Cell 53:137–144 (1988).

    Article  PubMed  CAS  Google Scholar 

  39. N. Sadmori, K. Miyuki, K. Nishino, et al., Abnormalities of chromosome 14 at band 14q11 in Japanese patients with chronic T-cell leukemia/ lymphoma, Cancer Genet. Cytogenet. 17:279–282 (1985).

    Article  Google Scholar 

  40. B. Vogelstein, E. R. Fearon, S. R. Hamilton, et al., Genetic alterations during colorectal-tumor development, N. Engl. J. Med. 319:525–532 (1988).

    Article  PubMed  CAS  Google Scholar 

  41. E. Solomon, R. Voss, V. Hall, et al., Chromosome 5 allele loss in human colorectal carcinomas, Nature 328:616–619 (1987).

    Article  PubMed  CAS  Google Scholar 

  42. L. A. Cannon-Albright, M. H. Skolnick, D. T. Bishop, et al., Common inheritance of susceptibility to colonic adenomatous polyps and associated colorectal cancers, N. Engl. J. Med. 319:533–537 (1988).

    Article  PubMed  CAS  Google Scholar 

  43. B. S. Danes, E. J. Gardner, and M. Lipkin, Studies on the identification of genetic risk for heritable colon cancer, Cancer Detect. Prev. 8:349–365 (1985).

    PubMed  CAS  Google Scholar 

  44. A. H. Parmiter and P. C. Nowell, The cytogenetics of human malignant melanoma and premalignant lesions, in: L. Nathanson, ed., “Malignant Melanoma: Biology, Diagnosis, and Therapy,” Kluwer Academic Publishers, Boston (1988).

    Google Scholar 

  45. J. M. Cowan, R. Halaban, and U. Francke, Cytogenetic analysis of melanocytes from premalignant nevi and melanomas, J. Natl. Cancer Inst. 80:1159–1164 (1988).

    Article  PubMed  CAS  Google Scholar 

  46. N. C. Dracopoli, B. Alhadeff, A. N. Houghton, et al., Loss of heterozygosity at autosomal and X-linked loci during tumor progression in a patient with melanoma, Cancer Res. 47:3995–4000 (1987).

    PubMed  CAS  Google Scholar 

  47. S. J. Bale, A. Chalravarti, and M. H. Greene, Cutaneous malignant melanoma and familial dysplastic nevi: Evidence for autosomal dominance and pleiotropy, Am. J. Hum. Genet. 38:188–196 (1986).

    PubMed  CAS  Google Scholar 

  48. S. H. Bigner, J. Mark, P. C. Burger, et al., Specific chromosomal abnormalities in malignant human gliomas, Cancer Res. 88:405–411 (1988).

    Google Scholar 

  49. C. D. James, E. Carlbom, J. P. Dumanski, et al., Clonal genomic alterations in glioma malignancy stages, Cancer Res. 48:5546–5551 (1988).

    PubMed  CAS  Google Scholar 

  50. M. J. Birrer and J. D. Minna, Molecular genetic of lung cancer, Semin. Oncol. 15:226–235 (1988).

    PubMed  CAS  Google Scholar 

  51. I. U. Ali, R. Lifereau, C. Theillet, et al., Reduction to homozygosity of genes on chromosome 11 in human breast neoplasia, Science 238:185–188 (1987).

    Article  PubMed  CAS  Google Scholar 

  52. M. J. van de Vijver, J. L. Peterse, W. J. Mooi, et al., Neu-protein overexpression in breast cancer: Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer, N. Engl. J. Med. 319:1239–1245 (1988).

    Article  PubMed  Google Scholar 

  53. E. P. Gelmann and M. E. Lippman, Understanding the role of oncogenes in human breast cancer, in: M. Sluyser, ed., “Growth Factors and Oncogenes in Breast Cancer,” Ellis Horwood Ltd., Chichester (England) (1987).

    Google Scholar 

  54. T. Boveri, Zur Frage der Entstehung maligner Tumoren, Gustave Fischer Verlag, Jena (Germany) (1914).

    Google Scholar 

  55. D. Von Hansemann, Uber asymmetrische Zellteilung in Epithelkrebsen und der biologische Bedeutung, Virchows Arch. Pathol. Anat. Physiol. 119:298–307 (1890).

    Google Scholar 

  56. J. German, ed., “Chromosome Mutation and Neoplasia, Alan R. Liss, New York (1983).

    Google Scholar 

  57. R. Sager, Genetic instability, suppression, and human cancer, in: L. Sachs, ed., “Gene Regulation in the Expression of Malignancy,” Oxford University Press, London (1985).

    Google Scholar 

  58. V. Ling, A. F. Chambers, J. F. Harris, et al., Quantitative genetic analysis of tumor progression, Cancer Metastasis Rev. 4:173–194 (1985).

    Article  PubMed  CAS  Google Scholar 

  59. R. Gantt, K. K. Sanford, R. Parshad, et al., Enhanced G2 chromatid radiosensitivity, an early stage in the neoplastic transformation of human epidermal keratinocytes in culture, Cancer Res. 47:1390–1397 (1987).

    PubMed  CAS  Google Scholar 

  60. J. Cairns, The origin of human cancers, Nature 289:353–357 (1981).

    Article  PubMed  CAS  Google Scholar 

  61. L. Loeb and L. Kunkel, Fidelity of DNA synthesis, Annu. Rev. Biochem. 52:429–457 (1982).

    Article  Google Scholar 

  62. G. Poste, J. Doll, and I. J. Fidler, Interactions between clonal sub-populations affect the stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells, Proc. Natl. Acad. Sci. USA 78:6226–6230 (1981).

    Article  PubMed  CAS  Google Scholar 

  63. W. C. Lambert and M. W. Lambert, DNA repair deficiency and cancer in xeroderma pigmentosum, Cancer Rev. 7:56–81 (1987).

    Google Scholar 

  64. F. Hecht, DNA ligase I, Bloom’s syndrome, and cancer, Cancer Genet. Cytogenet. 30:181–182 (1988).

    Article  PubMed  CAS  Google Scholar 

  65. J. J. Yunis and A. L. Soreng, Constitutive fragile sites and cancer, Science 226:1199–1204 (1984).

    Article  PubMed  CAS  Google Scholar 

  66. G. R. Sutherland and R. N. Simmers, No statistical association between common fragile sites and nonrandom chromosomal breakpoints in cancer cells, Cancer Genet. Cytogenet. 31:9–15 (1988).

    Article  PubMed  CAS  Google Scholar 

  67. M. B. Sporn and G. J. Todaro, Autocrine secretion and malignant transformation of cells, N. Engl. J. Med. 303:878–880 (1980).

    Article  PubMed  CAS  Google Scholar 

  68. M. Sluyser, ed., “Growth Factors and Oncogenes in Breast Cancer,” Ellis Horwood Ltd., Chichester (England) (1987).

    Google Scholar 

  69. E. Farber and C. Cameron, The sequential analysis of cancer development, Adv. Cancer Res. 31:125–225 (1980).

    Article  PubMed  CAS  Google Scholar 

  70. P. Nowell, Preleukemia: Cytogenetic clues in some confusing disorders, Am. J. Pathol. 89:459–476 (1977).

    PubMed  CAS  Google Scholar 

  71. B. N. Ames, R. Magaw, and L. S. Gold, Ranking possible carcinogenic hazards, Science 236:271–280 (1987).

    Article  PubMed  CAS  Google Scholar 

  72. K. Yamashina, B. E. Miller, and G. H. Heppner, Macrophage-mediated induction of drug-resistant variants in a mouse mammary tumor cell line, Cancer Res. 46:2396–2401 (1986).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Peter C. Nowell

Authors
  1. Peter C. Nowell
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Case Western Reserve University, Cleveland, Ohio, USA

    Oscar Sudilovsky

  2. McArdle Laboratory for Cancer Research, Madison, Wisconsin, USA

    Henry C. Pitot

  3. National Institutes of Health, Bethesda, Maryland, USA

    Lance A. Liotta

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Plenum Press, New York

About this chapter

Cite this chapter

Nowell, P.C. (1991). Genetic Instability and Tumor Development. In: Sudilovsky, O., Pitot, H.C., Liotta, L.A. (eds) Boundaries between Promotion and Progression during Carcinogenesis. Basic Life Sciences, vol 57. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5994-4_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5994-4_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5996-8

  • Online ISBN: 978-1-4684-5994-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation