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Red Blood Cell Aging pp 285–300Cite as

Phagocytosis of Phenylhydrazine Oxidized and G-6-PD Deficient Red Blood Cells: The Role of Sugars and Cell-Bound Immunoglobulins

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 307))

Abstract

Senescent or damaged red blood cells (RBCs) are selectively removed from the blood by macrophages in the spleen and liver (1). Changes observed in these cells involve various membranal modifications such as desialyzation (2–4), surface galactosyl exposure (5–7), degradation or configurai aggregation of band 3 (8-10) and changes in membrane phospholipid asymmetry (11,12). These modifications have been reported to be recognized by macrophages either directly (4–7,11,12), or indirectly, by binding of autoantibodies and complement components to the cells (2,8–10,13). Similar recognition mechanisms have been reported in some damaged RBCs such as in thalassemia and sickle cell anemia (10,11,14,15).

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Author information

Authors and Affiliations

  1. Dept. of Biochemistry, Microbiology and Immunology Faculty of Health Science, Ben-Gurion University, Beer-Sheva, Israel

    Sara Horn, Nava Bashan, Shimon Moses & Jacob Gopas

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  1. Sara Horn
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  2. Nava Bashan
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  3. Shimon Moses
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  4. Jacob Gopas
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Editor information

Editors and Affiliations

  1. University of Urbino, Urbino, Italy

    Mauro Magnani

  2. University of Genoa, Genoa, Italy

    Antonio De Flora

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© 1991 Plenum Press, New York

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Horn, S., Bashan, N., Moses, S., Gopas, J. (1991). Phagocytosis of Phenylhydrazine Oxidized and G-6-PD Deficient Red Blood Cells: The Role of Sugars and Cell-Bound Immunoglobulins. In: Magnani, M., De Flora, A. (eds) Red Blood Cell Aging. Advances in Experimental Medicine and Biology, vol 307. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5985-2_26

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  • DOI: https://doi.org/10.1007/978-1-4684-5985-2_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5987-6

  • Online ISBN: 978-1-4684-5985-2

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