Abstract
Although enterotoxigenic Escherichia coli (ETEC) is the most common cause of diarrhea in developing countries and in travelers to these areas, there is no ETEC vaccine available for use in humans. In developing countries ETEC diarrhea is mainly seen in children below 5 years and it has been estimated that as many as 650 million cases occur annually among these children, resulting in approximately 800.000 deaths [1]. ETEC is also the cause of 30–50% of all diarrheas in travelers to Latin America, Africa and Asia [1, 2, 3], i.e. between 2 and 3 million cases each year.
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References
R.E. Black, The epidemiology of cholera and enterotoxigenic E. coli diarrheal disease, in: “Development of vaccines and drugs against diarrhea,” 11th Nobel Conference, Stockholm, J. Holmgren, A. Lindberg and R. Mollby, eds., Studentlitteratur, Lund, p23 (1986).
R.L. Guerrant, Microbial toxins and diarrhoeal disease: introduction and overview, in: “Microbial toxins and diarrhoeal disease,” Ciba Foundation Symposium 112, Pitman, London, p1 (1985).
R. Steffen, Epidemiologic studies of travelers’ diarrhea, severe gastrointestinal infections, and cholera, Rev. of Infect. Dis. 8 (suppl 2):122 (1986).
C. M. Åhrén and A.-M. Svennerholm, Synergestic protective effect of antibodies against Escherichia coli enterotoxin and colonization factor antigens. Infect. Immun. 38:74 (1982).
Y. Lopez-Vidal, J.J. Calva, A. Trujillo, A.P. de Léon, A. Ramos, A.-M. Svennerholm, and G.M. Ruiz-Palacios, Enterotoxins and adhesins of enterotoxigenic Escherichia coli: Are they risk factors for acute diarrhea in the community? J. Infect. Dis. 162:442 (1990).
M.M. Levine, Escherichia coli that cause diarrhea: enterotoxigenic, enteropathogenic, enteroinvasive, enterohemoarrhagic and enteroadherent, J. Infect. Dis. 155:377 (1987).
M.M. Levine, R.E. Black, M.L. Clements, D.R. Nalin, L. Cisneros, and R.A. Finkelstein, Volunteer studies in development of vaccines against cholera and enterotoxigenic Escherichia coli: a review, in: “Acute Enteric Infections in Children. New prospects for treatment and prevention”, T Holme, J. Holmgren, M.H. Merson, R. Möllby, eds., Elsevier/North-Holland Biomedical Press, Amsterdam, p 443 (1981).
C.M. Ahren and A.-M. Svennerholm, Experimental enterotoxin-induced Escherichia coli diarrhea and protection induced by previous infection with bacteria of the same adhesin or enterotoxin type. Infect. Immun. 50:255 (1985).
B.J. Stoll, A.-M. Svennerholm, L. Gothefors, D. Barua, S. Huda, and J. Holmgren, Local and systemic antibody reponses to naturally acquired enterotoxigenic Escherichia coli diarrhea in an endemic area, J. Infect. Dis. 153:527 (1986).
L. Gothefors, C. Åhrén, B. Stoll, D.K. Barua, F. Ørskov, M. Salek, and A.-M. Svennerholm, Presence of colonization factor antigens on fresh isolates of fecal Escherichia coli. A prospective study, J. Infect. Dis. 152:1128 (1985).
A.-M. Svennerholm, C. Wennerås, J. Holmgren, M.M. McConnell, and B. Rowe, Roles of different coli surface antigens of colonization factor antigen II in colonization by and protective immunogenicity of enterotoxigenic Escherichia coli, Infect. Immun. 58:341 (1990).
A.-M. Svennerholm, Y. Lopez-Vidal, J. Holmgren, M.M. McConnell, and B. Rowe, Role of PCF8775 antigen and its coli surface subcomponents for colonization, disease, and protective immunogenicity of enterotoxigenic Escherichia coli in rabbits. Infect. Immun. 56:523 (1988).
J. Clemens, D. Sack, J.R. Harris, J. Chakraborty, P.K. Neogy, B. Stanton, et al., Cross-protection by B subunit-whole cell cholera vaccine against diarrhea associated with heat-labile toxin-producing enterotoxigenic Escherichia coli: results of a large-scale field trial. Infect. Dis. 158:372 (1988).
A.-M. Svennerholm, J. Holmgren, and D. A. Sack, Development of oral vaccines against enterotoxinogenic Escherichia coli diarrhoea. Vaccine 7:196 (1989).
J. Sanchez, A.-M. Svennerholm, and J. Holmgren, Genetic fusion of a non-toxic heat-stable enterotoxin-related decapeptide antigen to cholera toxin B-subunit, FEBS Lett. 241:110 (1988).
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© 1991 Plenum Press, New York
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Svennerholm, AM., Åhrén, C., Wennerås, C., Holmgren, J. (1991). Development of an Oral Vaccine Against Enterotoxigenic Escherichia coli Diarrhea. In: Wadström, T., Mäkelä, P.H., Svennerholm, AM., Wolf-Watz, H. (eds) Molecular Pathogenesis of Gastrointestinal Infections. Federation of European Microbiological Societies Symposium Series, vol 58. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5982-1_37
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DOI: https://doi.org/10.1007/978-1-4684-5982-1_37
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