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Association of Invasive Shigella Strains with Epithelial Cells

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Molecular Pathogenesis of Gastrointestinal Infections

Part of the book series: Federation of European Microbiological Societies Symposium Series ((FEMS,volume 58))

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Abstract

Shigellae are facultative intracellular parasites multiplying in the cytoplasm of the epithelial cells of the large intestine. The capability of shigellae to invade epithelial cells grown in tissue cultures showed a close correlation with their virulence (1). This phenotype is regulated by the growth temperature, and is related to the presence of a 140 Md plasmid. The plasmid codes for a set of proteins, some of which (ipaB, C, D) known to be essential for the invasiveness. However, the role(s) of these proteins in the invasion process is not known (for review see 2).

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Authors and Affiliations

  1. Institute of Microbiology, University Medical School, Pécs, Hungary

    Tibor Pál

  2. Department of Clinical Bacteriology, Karolinska Institute, Huddinge Hospital, Huddinge, Sweden

    Tibor Pál & Alf A. Lindbergh

Authors
  1. Tibor Pál
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  2. Alf A. Lindbergh
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Editor information

Editors and Affiliations

  1. University of Lund, Lund, Sweden

    T. Wadström

  2. National Public Health Institute, Helsinki, Finland

    P. H. Mäkelä

  3. University of Gothenburg, Gothenburg, Sweden

    A.-M. Svennerholm

  4. University of Umeå, Umeå, Sweden

    H. Wolf-Watz

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© 1991 Plenum Press, New York

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Pál, T., Lindbergh, A.A. (1991). Association of Invasive Shigella Strains with Epithelial Cells. In: Wadström, T., Mäkelä, P.H., Svennerholm, AM., Wolf-Watz, H. (eds) Molecular Pathogenesis of Gastrointestinal Infections. Federation of European Microbiological Societies Symposium Series, vol 58. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5982-1_29

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  • DOI: https://doi.org/10.1007/978-1-4684-5982-1_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5984-5

  • Online ISBN: 978-1-4684-5982-1

  • eBook Packages: Springer Book Archive

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