Direct Actions of Volatile Anesthetics on the Coronary Vasculature
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Blood vessels determine the distribution of cardiac output to the various body organs, and successful performance of this function necessitates a high degree of regulation of the vascular system. These regulatory processes involve both neurohumoral factors under nervous system control, and local control of vascular resistance within each bed being perfused. Thus, when attempting to understand the mechanisms of vascular action of hemodynamically active drugs such as halothane, it is important to distinguish their direct vascular effects (mediated by direct interaction of the anesthetic with the blood vessel) from their indirect vascular actions.
KeywordsCoronary Flow Coronary Flow Reserve Volatile Anesthetic Coronary Vascular Resistance Vascular Action
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- 1.J. L. Seagard, Z. J. Bosnjak, F. A. Hopp, Jr., K. J. Kotrly, T. J. Ebert and J. P. Kampine, Cardiovascular effects of general anesthesia, in: “Effects of Anesthesia,” B. G. Covino, H. A. Fozzard, K. Render, G. Strichartz, eds., American Physiological Society, Bethesda, pp. 149–177 (1985).Google Scholar
- 9.L. Sahlman, B. Å. Henriksson, J. Martner and S. E. Ricksten, Effects of halothane, enflurane, and isoflurane on coronary vascular tone, myocardial performance, and oxygen consumption during controlled changes in aortic and left atrial pressure: studies on isolated working rat hearts in vitro. Anesthesiology 69:1–10 (1988).PubMedCrossRefGoogle Scholar