Direct Actions of Volatile Anesthetics on the Coronary Vasculature

  • David R. Larach
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 301)


Blood vessels determine the distribution of cardiac output to the various body organs, and successful performance of this function necessitates a high degree of regulation of the vascular system. These regulatory processes involve both neurohumoral factors under nervous system control, and local control of vascular resistance within each bed being perfused. Thus, when attempting to understand the mechanisms of vascular action of hemodynamically active drugs such as halothane, it is important to distinguish their direct vascular effects (mediated by direct interaction of the anesthetic with the blood vessel) from their indirect vascular actions.


Coronary Flow Coronary Flow Reserve Volatile Anesthetic Coronary Vascular Resistance Vascular Action 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • David R. Larach
    • 1
  1. 1.Department of Anesthesia, College of MedicineThe Pennsylvania State UniversityHersheyUSA

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