Interactions of Volatile Anesthetics and Reactive Oxygen Intermediates on Vascular Smooth Muscle
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Reactive oxygen intermediates (ROIs, also referred to as oxygen-derived free radicals or reactive oxygen metabolites) have been implicated in several physiological and pathological processes.1–3 In particular, they have been reported to be associated with several vascular abnormalities, including those that occur during hypertension,4 reperfusion injury,5 transplant rejection,3 inflammation, premature aging,6 radiation injury, diabetes7 and endotoxic shock.8 An increase in PaO2, especially after hypoxia, is a major stimulus for production of ROIs.9
KeywordsVolatile Anesthetic Reactive Oxygen Intermediate Vascular Ring Laser Illumination Oxygen Radical Production
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