Abstract
The volatile anesthetics, halothane and isoflurane, cause cerebral vasodilation, especially at concentrations required to induce deep planes of anesthesia. Furthermore, most,1,2,3 but not all,4,5 studies in animals have demonstrated that isoflurane causes less cerebral vasodilation than halothane. However, low concentrations of either volatile anesthetic do not appear to affect the cerebral blood flow (CBF). Manohar and Parks6 demonstrated that CBF in swine models was not significantly altered at 1 MAC isoflurane. Similar observations were made by Cucchiara et al. 1 in dogs. Murphy et al. 7 reported no change in CBF in humans receiving 0.6 MAC halothane or 1.1 MAC isoflurane.
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© 1991 Plenum Press, New York
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Flynn, N., Buljubasic, N., Bosnjak, Z.J., Kampine, J.P. (1991). Cerebral Vascular Responses to Anesthetics. In: Blanck, T.J.J., Wheeler, D.M. (eds) Mechanisms of Anesthetic Action in Skeletal, Cardiac, and Smooth Muscle. Advances in Experimental Medicine and Biology, vol 301. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5979-1_22
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DOI: https://doi.org/10.1007/978-1-4684-5979-1_22
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