Anesthetic Effects on Vascular Smooth Muscle

  • Sheila M. Muldoon
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 301)


For many years it was generally believed that volatile anesthetic agents, with the exception of diethyl ether and cyclopropane, had a depressant effect on the vascular system. Because the physiological effects of anesthetic agents were measured in man and whole animal, the precise site or sites of action could not be determined. In 1962 Price and Price,1 using isolated tissue and standardized experimental conditions, reported that the effect of halothane was primarily at the adrenergic receptor on the vascular smooth muscle (VSM) cell. Other studies2 concluded that although the response to norepinephrine (NE) in VSM was depressed by halothane, antagonism between NE and halothane was difficult to explain in terms of classical pharmacological kinetics.


Vascular Smooth Muscle Coronary Blood Flow Inositol Phosphate Volatile Anesthetic Anesthetic Action 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Sheila M. Muldoon
    • 1
  1. 1.Depatment of AnesthesiologyUniformed Services University of the Health SciencesBethesdaUSA

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