Contribution of the Known Subcellular Effects of Anesthetics to Their Negative Inotropic Effect in Intact Myocardium

  • Hirochika Komai
  • Ben F. Rusy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 301)


Various anesthetics have been shown to affect virtually every step involved in myocardial excitation-contraction coupling. What is not known is the relative importance of these multiple effects to the overall negative inotropic response in intact myocardium. We have used isolated rabbit papillary muscles and left atrial muscles to evaluate the relative contribution of anesthetic effects on the transsarcolemmal Ca2+ influx, on the function of the sarcoplasmic reticulum, and on the response of the myofibril.


Sarcoplasmic Reticulum Control Force Muscle Length Negative Inotropic Effect Anesthetic Effect 
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  1. 1.
    H. Komai and B. F. Rusy, Direct effect of halothane and isoflurane on the function of the sarcoplasmic reticulum in intact rabbit atria, Anesthesiology 72:694–698 (1990).PubMedCrossRefGoogle Scholar
  2. 2.
    M. C. Capogrossi, M. M. Kort, H. A. Spurgeon and E. G. Lakatta, Single adult rabbit and rat cardiac myocytes retain the Ca2+-and species-dependent systolic and diastolic contractile properties of intact muscle, J Gen Physiol 88:589–613 (1986).PubMedCrossRefGoogle Scholar
  3. 3.
    D. M. Wheeler, R. T. Rice, R. G. Hansford and E. G. Lakatta, The effect of halothane on the free intracellular calcium concentration of isolated rat heart cells, Anesthesiology 69:578–583 (1988).PubMedCrossRefGoogle Scholar
  4. 4.
    C. Lynch III, S. Vogel and N. Sperelakis, Halothane depression of myocardial slow action potentials, Anesthesiology 55:360–368 (1981).PubMedCrossRefGoogle Scholar
  5. 5.
    H.-N. Luk, C.-I. Lin, C.-L. Chang and A.-R. Lee, Differential inotropic effects of halothane and isoflurane in dog ventricular tissues, Eur J Pharmacol 136:409–413 (1987).PubMedCrossRefGoogle Scholar
  6. 6.
    D. M. Wheeler, R. T. Rice and E. G. Lakatta, The action of halothane on spontaneous contractile waves and stimulated contractions in isolated rat and dog heart cells, Anesthesiology 72:911–920 (1990).PubMedCrossRefGoogle Scholar
  7. 7.
    S. Kurihara and T. Sakai, Effects of rapid cooling on mechanical and electrical responses in ventricular muscle of guinea-pig, J Physiol (Lond) 361:361–378 (1985).PubMedGoogle Scholar
  8. 8.
    J. H. B. Bridge, Relationships between the sarcoplasmic reticulum and sarcolcmmal calcium transport revealed by rapidly cooling rabbit ventricular muscle, J Gen Physiol 88:437–473 (1986).PubMedCrossRefGoogle Scholar
  9. 9.
    T. J. J. Blanck and R. L. Stevenson, Thiopental does not alter Ca2+ uptake by cardiac sarcoplasmic reticulum, Anesth Anaig 67:346–348 (1988).Google Scholar
  10. 10.
    H. Komai, D. Redon and B. F. Rusy, Effects of isofluranc and halothane on rapid cooling contractures in myocardial tissue, Am J Physiol 257:H1804–H1811 (1989).PubMedGoogle Scholar
  11. 11.
    D. G. Allen and J. C. Kentish, The cellular basis of the length-tension relation in cardiac muscle. J Mol Cell Cardiol 17:821–840 (1985).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Hirochika Komai
    • 1
  • Ben F. Rusy
    • 1
  1. 1.Department of AnesthesiologyUniversity of WisconsinMadisonUSA

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