Halothane Inhibits Binding of Calcium Channel Blockers to Cardiac Sarcolemma

  • Benjamin Drenger
  • Susan Riggs Runge
  • Paul Hoehner
  • Mary Quigg
  • Thomas J. J. Blanck
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 301)


Several pieces of evidence exist which suggest that the volatile anesthetics exert their negative inotropic effect by interfering with the calcium homeostasis of the myocardial cell.1 Our laboratory has examined three important sites in the myocardial cell that are known to be involved with the phasic changes in intracellular calcium which occur during contraction. These sites are the sarcolemma, the sarcoplasmic reticulum, and the myofibrils. This paper is directed towards our investigations of one constituent of the sarcolemma, the voltage-dependent calcium channel (VDCC), and its probable alteration by the volatile anesthetic, halothane.


Sarcoplasmic Reticulum Volatile Anesthetic Anesthetic Action Sarcolemmal Membrane Halothane Concentration 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Benjamin Drenger
    • 1
  • Susan Riggs Runge
    • 2
  • Paul Hoehner
    • 2
  • Mary Quigg
    • 2
  • Thomas J. J. Blanck
    • 2
  1. 1.Department of Anesthesiology, Cardiothoracic Anesthesia UnitHadassah HospitalJerusalemIsrael
  2. 2.Division of Cardiac Anesthesia, Department of Anesthesiology and Critical Care MedicineJohns Hopkins UniversityBaltimoreUSA

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