Skeletal Muscle Targets for the Action of Anesthetic Agents

  • Thomas E. Nelson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 301)


Prior to its meeting in Augusta, Georgia in 1988, this group decided to focus on anesthetic action on skeletal muscle at sites distal to the myoneural junction. Therefore, in this summary chapter, targets for anesthetic action will be described beginning at the sarcolemma (excluding the motor endplate) and ending with the intracellular contractile elements. This section is not intended as a review, but rather as an overview and preview to some of the interesting investigations on skeletal muscle presented at this conference.


Skeletal Muscle Rest Membrane Potential Malignant Hyperthermia Compound Action Potential Anesthetic Action 
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  1. 1.
    B. E. Waud and D. R. Waud, Effects of volatile anesthetics on directly and indirectly stimulated skeletal muscle, Anesthesiology 50:103–110 (1979).PubMedCrossRefGoogle Scholar
  2. 2.
    J. J. Kendig and J. P. Bunker, Alterations in muscle resting potentials and electrolytes during halothane and cyclopropane anesthesia, Anesthesiology 36:128–131 (1972).PubMedCrossRefGoogle Scholar
  3. 3.
    S. Kurihoro, M. Konishi, T. Myagishima and T. Sakai, Effects of enflurane on excitation-contraction coupling in frog skeletal muscle fibers, Pflugers Arch 402:345–352 (1984).CrossRefGoogle Scholar
  4. 4.
    E. M. Gallant, Porcine malignant hyperthermia: no role for plasmalemmal depolarization, Muscle and Nerve 11:785–786 (1988).PubMedGoogle Scholar
  5. 5.
    B. P. Bean, P. Shoryer and D. A. Goldstein, Modification of sodium and potassium channel gating kinetics by ether and halothane, J Gen Physiol 77:233–253 (1981).PubMedCrossRefGoogle Scholar
  6. 6.
    J. P. Ruppersberg and R. Rudel, Differential effects of halothane on adult and juvenile sodium channels in human muscle, Pflugers Arch 412:17–21 (1988).PubMedGoogle Scholar
  7. 7.
    F. A. Lai, H. P. Erickson, E. Rousseau, O.-Y. Liu, G. Meissner, Purification and reconstitution of the calcium release channel from skeletal muscle, Nature 331:315–319 (1988).PubMedCrossRefGoogle Scholar
  8. 8.
    M. Fill, E. Stefani, T. E. Nelson, Abnormal human sarcoplasmic reticulum Ca2+ release channels in malignant hyperthermia skeletal muscle, Biophys J (In Press)Google Scholar
  9. 9.
    M. Fill, R. Coronado, J. R. Mickelson, J. Vilven, J. Mo, B. A. Jacobson and C. F. Louis, Abnormal ryanodine receptor channels in malignant hyperthermia, Biophys J 57:471–476 (1990).PubMedCrossRefGoogle Scholar
  10. 10.
    P. A. Deuster, E. L. Blackman and S. M. Muldoon, In vitro responses of cat skeletal muscle to halothane and caffeine, J Appl Physiol 58:521–527 (1985).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Thomas E. Nelson
    • 1
  1. 1.Department of AnesthesiologyUniversity of Texas Health Science CenterHoustonUSA

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