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Mechanisms and Specificity of HIV Entry into Host Cells pp 17–26Cite as

Molecular Analysis of Receptor Binding and Viral Tropism

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 300))

Abstract

Human Immunodeficiency Virus (HIV), the etiologic agent of AIDS (Acquired Immunodeficiency Syndrome) displays a selective tropism for CD4-positive lymphocytes and for CD4-positive cells of the mononuclear-phagocyte lineage. Infection of target cells is initiated by the specific interaction of HIV envelope protein gpl20 and the CD4 molecule on the cell surface1,2,3. Despite extensive genetic variation of gpl20 among different HIV isolates, each uses the CD4 molecule as a cellular receptor. Furthermore, both the HIV-1 and HIV-2 interact with the same epitopes on the CD4 molecule4,5 while the extracellular envelope proteins of these two viruses display little antigenic cross-reactivity and share only 40% overall amino acid identity6. This suggests that conserved regions of gpl20 are involved in binding to the CD4 molecule.

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Authors and Affiliations

  1. Unité d’Oncologie Virale (CNRS UA 1157), Institut Pasteur, 75724, Paris Cedex 15, France

    A. Cordonnier & L. Montagnier

Authors
  1. A. Cordonnier
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  2. L. Montagnier
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Editor information

Editors and Affiliations

  1. University of the Pacific, San Francisco, California, USA

    Nejat Düzgüneş

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© 1991 Plenum Press, New York

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Cordonnier, A., Montagnier, L. (1991). Molecular Analysis of Receptor Binding and Viral Tropism. In: Düzgüneş, N. (eds) Mechanisms and Specificity of HIV Entry into Host Cells. Advances in Experimental Medicine and Biology, vol 300. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5976-0_2

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  • DOI: https://doi.org/10.1007/978-1-4684-5976-0_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5978-4

  • Online ISBN: 978-1-4684-5976-0

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