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Fusion of HIV-1 and SIVmac with Liposomes and Modulation of HIV-1 Infectivity

  • Chapter
Mechanisms and Specificity of HIV Entry into Host Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 300))

Abstract

Human immunodeficiency virus (HIV) and simian immunodeficiency virus from macaques (SIVmac) are the etiological agents of the acquired immunodeficiency syndrome (AIDS), and simian AIDS, respectively (Barré-Sinoussi et al., 1983; Gallo et al, 1984; Levy et al, 1984; Clavel et al., 1986; Letvin et al., 1985; De Vita et al., 1988). The genetic sequence of SIVmac is closely related to that of HIV-2 (Chakrabarti et al, 1987) and HIV-1 (Chakrabarti et al., 1987; Desrosiers, 1988), and infection of macaques by SIVmac represents the best animal model for human AIDS. The molecular and cellular mechanisms of entry of these viruses into their host cells are not well understood. The involvement of an endocytosis step before the fusion of the HIV-1 envelope with cellular membranes, and the requirement for acidic pH for fusion are topics of controversy (Maddon et al., 1986, 1988; Stein et al., 1987; Pauza and Price, 1988; McClure et al., 1988).

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Authors and Affiliations

  1. Cancer Research Institute, University of California, San Francisco, CA, 94143, USA

    Nejat Düzgüneş, Charles E. Larsen, Krystyna Konopka, Dennis R. Alford & Shlomo Nir

  2. Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, 94143, USA

    Nejat Düzgüneş

  3. Department of Microbiology, University of the Pacific, School of Dentistry, San Francisco, CA, 94115, USA

    Nejat Düzgüneş

  4. California Primate Research Center, University of California, Davis, CA, 95616, USA

    Lawrence J. T. Young & Thomas P. McGraw

  5. Medical Research Institute of San Francisco at Pacific Presbyterian Medical Center, San Francisco, CA, 94115, USA

    Brian R. Davis

  6. Department of Soil and Water Sciences, The Hebrew University of Jerusalem, Rehovot, 76100, Israel

    Shlomo Nir

  7. Comparative Oncology Laboratory, University of California, Davis, CA, 95616, USA

    Myra Jennings

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  1. University of the Pacific, San Francisco, California, USA

    Nejat Düzgüneş

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© 1991 Plenum Press, New York

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Düzgüneş, N. et al. (1991). Fusion of HIV-1 and SIVmac with Liposomes and Modulation of HIV-1 Infectivity. In: Düzgüneş, N. (eds) Mechanisms and Specificity of HIV Entry into Host Cells. Advances in Experimental Medicine and Biology, vol 300. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5976-0_11

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  • DOI: https://doi.org/10.1007/978-1-4684-5976-0_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5978-4

  • Online ISBN: 978-1-4684-5976-0

  • eBook Packages: Springer Book Archive

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