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Thyroid Function in the Preterm Infant

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Advances in Perinatal Thyroidology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 299))

Abstract

Postnatal thyroid function in the preterm infant is dependent on the neonate’s gestational maturity, intrauterine growth and birth weight, and state of health. In general, in larger premature infants the pattern of pituitary-thyroid function is qualitatively similar but quantitatively less than that in the term infant, whereas in the smaller (<1,000 g, <30 weeks) preterm infant there is delay in activation of pituitary-thyroid function (1, 2).

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References

  1. Fisher DA, Klein AH. Thyroid development and disorders of thyroid function in the newborn. N Engl J Med 304: 702–712, 1981.

    Article  PubMed  CAS  Google Scholar 

  2. Fisher DA, Hobel CJ, Jarza R, Pierce CA. Thyroid function in the preterm fetus. Pediatrics 46: 208–215, 1970.

    PubMed  CAS  Google Scholar 

  3. Gorodzinsky P, Howard NJ, Ginsberg J, Walfish PG. Cord serum thyroxine and thyrotropin values between 20 and 30 weeks’ gestation. J Pediatr 94: 971–973, 1979.

    Article  PubMed  CAS  Google Scholar 

  4. Oddie TH, Fisher DA, Bernard B, Lamb KW. Thyroid function at birth in infants 30 to 45 weeks gestation. J Pediatr 90: 803–806, 1977.

    Article  PubMed  CAS  Google Scholar 

  5. Greenberg AH, Czernichow P, Reba RC, Tyson J, Blizzard RM. Observations on the maturation of thyroid function in early fetal life. J Clin Invest 49: 1790–1803, 1970.

    Article  PubMed  CAS  Google Scholar 

  6. Hirano T, Singh J, Srinivasan T, Pildes R. Postnatal thyroid function in low birth weight infants; a cross-sectional assessment of free thyroxine and thyroid hormone binding globulin. Eur J Pediatr 139: 244–246, 1982.

    Article  PubMed  CAS  Google Scholar 

  7. Jacobsen BB. Thyroid function in infancy. Danish Medical Bulletin, 30: 281–309, 1983.

    PubMed  CAS  Google Scholar 

  8. Fisher DA, Dussault JH, Hobel CJ, Lam R. Serum and thyroid gland triiodothyronine in the human fetus. J Clin Endocrinol Metabol 36: 397–400, 1973.

    Article  CAS  Google Scholar 

  9. Isaac RM, Hayek A, Standefer JC, Eaton RP. Reverse triiodothyronine to triiodothyronine ratio and gestational age. J Pediatr 94:477–479, 1979.’

    CAS  Google Scholar 

  10. Klein AH, Foley B, Kenny FM, Fisher DA. Thyroid hormone and thyrotropin responses to parturition in premature infants with and without the respiratory distress syndrome. Pediatrics 63: 380–385, 1979.

    PubMed  CAS  Google Scholar 

  11. Uhrmann S, Marks KH, Maisels MG, Kulin HE, Kaplan M, Utiger R. Frequency of transient hypothyroxinemia in low birth weight infants. Arch Dis Child 56: 214–217, 1981.

    Article  PubMed  CAS  Google Scholar 

  12. Kok JH, Tegelaers WH, deVijlder JJ.Serum thyroglobulin levels in preterm infants with and without respiratory distress syndrome II. A longitudinal study during the first three weeks of life. Pediatr Res 20: 1001–1003, 1986.

    Article  PubMed  CAS  Google Scholar 

  13. Jacobsen BB, Anderson HJ, Peitersen B, DigePeterson H and Hummer L. Serum levels of thyrotropin, thyroxine and triiodothyronine in full term, small for gestational age and preterm newborn babies. Acta Paediatr Scand66: 681–687, 1977.

    Article  PubMed  CAS  Google Scholar 

  14. Whiteside WH, Williams PR, Root AW, Strezlecki J, Curran JS, Kanarek K. Serum thyroxine (T4), free T4 (FT4) and TSH in premature infants less than 1000 grams during the first three months of life. Pediatr Res 18: 179A, 1984.

    Google Scholar 

  15. John R, Bamford FJ. Serum free thyroxine and free triiodothyronine concentrations in healthy full term, preterm and sick preterm neonates. Ann Biochem 24: 461–465, 1987.

    Google Scholar 

  16. Mercado N, Yu VY, Francis I, Szymonowicz W, Gold H. Thyroid function in very preterm infants. Early Hum Devel 16: 131–141, 1988.

    Article  CAS  Google Scholar 

  17. Bongers-Schokking JJ, Schopman WS. Thyroid function in healthy normal, low birth weight and preterm infants. Eur J Pediatr 143: 117–122, 1984.

    Article  PubMed  CAS  Google Scholar 

  18. Lucas A, Rennie J, Baker BA, Morley R. Low plasma triiodothyronine concentrations and outcome in preterm infants. Arch Dis Child 63: 1201–1206, 1988.

    Article  PubMed  CAS  Google Scholar 

  19. Hadeed AJ, Asay LD, Klein AH, Fisher DA. Significance of transient postnatal hypothyroxinemia in premature infants with and without respiratory distress syndrome. Pediatrics 68: 494–498, 1981.

    PubMed  CAS  Google Scholar 

  20. Chowdhry P, Scanlon JW, Auerbach R, Abassi V. Results of a controlled double blind study of thyroid replacement in very low birth weight premature infants with hypothyroxinemia. Pediatrics 73:301–305, 1984.

    CAS  Google Scholar 

  21. DeVries LS, Heckmatt JZ, Bunnin JM, Dubowitz LMS, Dubowitz V. Low serum thyroxine concentrations and neural maturation in preterm infants. Arch Dis Child 61: 862–866, 1986.

    Article  CAS  Google Scholar 

  22. Klein AH, Foley B, Foley TP, MacDonald HM, Fisher DA. Thyroid function studies in cord blood from premature infants with and without RDS. J Pediatr 98: 818–820, 1981.

    Article  PubMed  CAS  Google Scholar 

  23. Franklin RC, Purdie GL, O’Grady CM. Neonatal thyroid function: prematurity, prenatal steroids, and respiratory distress syndrome. Arch Dis Child 61: 589–562, 1986.

    Article  PubMed  CAS  Google Scholar 

  24. Abassi V, Merchant K, Abramson D. Postnatal triiodothyronine concentrations in healthy preterm infants and infants with respiratory distress syndrome. Pediatric Res 11: 800–804, 1977.

    Article  Google Scholar 

  25. Jacobsen BB, Peitersen B, Hummer L. Serum concentrations of thyrotropin, thyroid hormones and thyroid hormone binding proteins during acute and recovery stages of idiopathic respiratory distress syndrome. Acta Paediatr Scand 68: 257–264, 1979.

    Article  PubMed  CAS  Google Scholar 

  26. Schonberger W, Grimm W, Emmrich P, Gempp W. Reduction of mortality rate in premature infants by substitution of thyroid hormones. Eur J Pediatr 135: 245–253, 1981.

    Article  PubMed  CAS  Google Scholar 

  27. Cuestas RA. Thyroid function in healthy premature infants, J Pediatr 91: 963–967, 1978.

    Google Scholar 

  28. Ginsberg J, Walfish PG, Chopra IJ. Cord blood reverse T3 in normal, premature, euthyroid low T4 and hypothyroid newborns. J Endocrinol Invest 1: 73–77, 1978.

    PubMed  CAS  Google Scholar 

  29. Diamond FB, Parks JS, Tenore A, Marino JM, Borgiovanni AM. Hypothyroxinemia in sick and well preterm infants. Clin Pediatr 18: 555–561, 1971.

    Article  Google Scholar 

  30. Hirano T, Singh J, Srinivasan G, Pildes R. Postnatal thyroid function in low birth weight infants; a longitudinal assessment of free thyroxine and thyroid hormone binding globulin. Acta Endocrinol 110: 56–60, 1985.

    PubMed  CAS  Google Scholar 

  31. Nagashima K, Onoda K, Suzuki S, Sakaguchi M, Kuroume T. Reevaluation of thyroid function in low birth weight infants based on free triiodothyronine and triiodothyronine. Biol Neonate 48: 341–345, 1985.

    Article  PubMed  CAS  Google Scholar 

  32. Erenberg A, Phelps DL, Lam R, Fisher DA. Total and free thyroid hormone concentrations in the neonatal period. Pediatrics 53: 211–216, 1974.

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pediatrics, University of South Florida College of Medicine and All Children’s Hospital, St. Petersburg, Florida, USA

    Allen W. Root & Allen W. Root

Authors
  1. Frank B. Diamond Jr.
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  2. Allen W. Root
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Editor information

Editors and Affiliations

  1. College of Medicine, University of South Florida, Tampa, Florida, USA

    Barry B. Bercu  & Dorothy I. Shulman  & 

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© 1991 Plenum Press, New York

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Diamond, F.B., Root, A.W. (1991). Thyroid Function in the Preterm Infant. In: Bercu, B.B., Shulman, D.I. (eds) Advances in Perinatal Thyroidology. Advances in Experimental Medicine and Biology, vol 299. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5973-9_13

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  • DOI: https://doi.org/10.1007/978-1-4684-5973-9_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5975-3

  • Online ISBN: 978-1-4684-5973-9

  • eBook Packages: Springer Book Archive

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