Abstract
The etiology of congenital hypothyroidism is unknown in most cases although there is a greater incidence of thyroid disease in families of infants with sporadic cretinism (1). The occurrence of thyroid dysgenesis in more than one member of a family has not helped to resolve the genetic factors involved. In Japan an association with HLA type AW24 has been reported whereas in North America and Europe such an association has not been confirmed (2,3). On the other hand, Shepard reported an increased incidence of non-tasters of phenylthiocarbamide in families of a member with sporadic hypothyroidism (4). Since the ability to taste Phenylthiocarbamide is a recessive inherited trait and since there is a lower incidence of non-tasters among blacks, a lower incidence of the disease was expected in the black population, a fact that was confirmed in North America (5).
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© 1991 Plenum Press, New York
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Dussault, J.H. (1991). Congenital Hypothyroidism: New Insight Regarding Etiology. In: Bercu, B.B., Shulman, D.I. (eds) Advances in Perinatal Thyroidology. Advances in Experimental Medicine and Biology, vol 299. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5973-9_11
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DOI: https://doi.org/10.1007/978-1-4684-5973-9_11
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