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Huntington’s Disease

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Advances in Human Genetics

Part of the book series: Advances in Human Genetics ((AHUG,volume 20))

Abstract

Huntington’s disease (HD) is an autosomal dominant disorder characterized by onset in adult life of progressive involuntary choreiform movements, and dementia (1). Though others had previously recognized the disorder, it only received widespread attention after a comprehensive description was published by George Huntington in 1872 (2). Huntington, a physician on Long Island, not only provided an excellent clinical summary of the movement disorder, but, because his patients in East Hampton were the progeny of similarly affected individuals previously treated by his father and grandfather, he also noted the inherited nature of the disease. For some of these families, the disease has been traced to ancestors who immigrated from Bures, England, landing in New England in 1649 (3,4).

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Authors and Affiliations

  1. Department of Genetics, Harvard Medical School, Cambridge, Massachusetts, USA

    James F. Gusella

  2. Molecular Neurogenetics Laboratory, Massachusetts General Hospital, Charlestown, Massachusetts, 02129, USA

    James F. Gusella

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  1. James F. Gusella
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Editors and Affiliations

  1. University of Pennsylvania, Philadelphia, USA

    Harry Harris (Harnwell Professor of Human Genetics) (Harnwell Professor of Human Genetics)

  2. Mount Sinai School of Medicine of The City University of New York, USA

    Kurt Hirschhorn (Herbert H. Lehman Professor and Chairman of Pediatrics) (Herbert H. Lehman Professor and Chairman of Pediatrics)

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© 1991 Plenum Press, New York

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Gusella, J.F. (1991). Huntington’s Disease. In: Harris, H., Hirschhorn, K. (eds) Advances in Human Genetics. Advances in Human Genetics, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5958-6_3

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  • DOI: https://doi.org/10.1007/978-1-4684-5958-6_3

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