Abstract
Although human milk is the main source of nutrition for infants, for many years artificial formulas based on cow’s milk have been introduced into infant nutrition. It is known that human milk contains far less protein but many more free amino acids (Lönnerdal et al., 1976; Svanberg et al., 1977) than cow’s milk (Macy et al., 1953; Fomon, 1974; Lee and Lorenz, 1978; George and Lebenthal, 1981). Studies on the content of free amino acids in milk have excluded tryptophan for methodological reason, and consequently little is known of the nutritional factors that may influence its availabil-lity in early life (Tricklebank et al., 1979; De Antoni et al., 1980). Tryptophan is in effect the only amino acid bound between 80 and 90% to plasma albumin. Only the small free fraction is able to cross the haematoencephalic barrier to enter the brain to form serotonin (McMenamy and Oncley, 1958).
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References
Costa, C., Bettero, A., and Allegri, G., 1987, Rapid measurement of trypto-phan, 5-hydroxytryptophan, serotonin and 5-hydroxyindoleacetic acid in human CSF by selective fluorescence and HPLC, Gior. Ital. Chim. Clin., 12: 307–312.
De Antoni, A., Allegri, G., Costa, C., Vanzan, S., Bertolin, A., Carretti, N., and Zanardo, V., 1980, Total and free tryptophan in serum of newborn infants, Acta Vitaminol. Enzymol., 2: 17–20.
Fernstrom, J.D., and Wurtman, R.J., 1971, Brain serotonin content: physiological dependence on plasma tryptophan levels, Science, 173: 149–159.
Fomon, S.J., 1974, Infant Nutrition, W.B. Saunders, Philadelphia, p. 575.
George, D.E., and Lebenthal, E., 1981, Human breast milk in comparison to cow’s milk, in: “Textbook of Gastroenterology and Nutrition in Infancy”, Lebenthal, E., ed., Raven Press, New York, pp. 295–320.
Lee, V.A., and Lorenz, K., 1978, The nutritional and physiological impact of milk in human nutrition, CRC Crit. Rev. Food Sci. Nutr., 11: 41–116.
Lönnerdal, B., Forsum, E., and Hambraeus, L., 1976, A longitudinal study of the protein, nitrogen, and lactose contents of human milk from Swedish well-nourished mothers, Am. J. Clin. Nutr., 29: 1127–1133.
Macy, I.G., Kelly, H.J., and Sloan, R.E., 1953, The composition of milks, in: “National Academy of Science Research Council”, Publ. 254, Washington, D.C., p. 70.
McMenamy, R.H., and Oncley, J.L., 1958, The specific binding of L-tryptophan to serum albumin, J. Biol. Chem., 233: 1436–1447.
Svanberg, U., Gebre-Medhin, M., Ljungqvist, B., and Olsson, M., 1977, Breast milk composition in Ethiopian and Swedish mothers. III. Amino acids and other nitrogenous substances, Am. J. Clin. Nutr., 30: 499–507.
Tricklebank, M.D., Pickard, F.J., and De Souza, S.W., 1979, Free and bound tryptophan in human plasma during the perinatal period, Acta Paediatr. Scand., 68: 199–204.
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© 1991 Plenum Press, New York
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Biasiolo, M., Costa, C., Bettero, A., Allegri, G. (1991). Levels of Non-Proteic Tryptophan in Milk and Soybean Formulas. In: Schwarcz, R., Young, S.N., Brown, R.R. (eds) Kynurenine and Serotonin Pathways. Advances in Experimental Medicine and Biology, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5952-4_83
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DOI: https://doi.org/10.1007/978-1-4684-5952-4_83
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