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Endocrine Response of Prolactin, Cortisol, and Growth Hormone to Low Dose Intravenous L-Tryptophan in Healthy Subjects During Day and Night

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Kynurenine and Serotonin Pathways

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 294))

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Abstract

Neuroendocrine responses to intravenous (i.v.) administered L-trypto-phan (LTP) seem to be an index of brain serotonin (5-HT) function (Meites and Sonntag, 1981; Meltzer et al., 1982; Cowen, 1987, 1988). 5-HT seriously affects the regulation of the sleep wake cycle (Jouvet, 1984). Pituitary gland hormones such as growth hormone (GH), prolactin (PRL), and cortisol, show nycthemeral rhythmicity. Sleep as a part of a circadian rhythm has a masking effect on these hormones: maximal on GH, but minimal on cortisol (Parker et al., 1980; Clarenbach and Ries, 1985).

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© 1991 Plenum Press, New York

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Hajak, G., Rodenbeck, A., Blanke, J., Wuttke, W., Rüther, E. (1991). Endocrine Response of Prolactin, Cortisol, and Growth Hormone to Low Dose Intravenous L-Tryptophan in Healthy Subjects During Day and Night. In: Schwarcz, R., Young, S.N., Brown, R.R. (eds) Kynurenine and Serotonin Pathways. Advances in Experimental Medicine and Biology, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5952-4_77

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  • DOI: https://doi.org/10.1007/978-1-4684-5952-4_77

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5954-8

  • Online ISBN: 978-1-4684-5952-4

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