Abstract
Kynurenic acid, the product of kynurenine aminotransferase, has increasingly attracted attention because of its physiological effects in the brain, such as blockade of the neurotoxicity induced by quinolinic acid in rat (Foster et al., 1984) or decrease of the stroke size and deficits in human (Germano et al., 1987). Also, it can protect neonatal rats from hypoxia-induced brain edema (Simon et al., 1986).
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References
Carlà, V., Lombardi, G., Beni, M., Russi, P., Moneti, G., and Moroni, F., 1988, Identification and measurement of kynurenic acid in the rat brain and other organs, Anal. Biochem., 169: 89–94.
Foster, A.C., Vezzani, A., French, E.D., and Schwarcz, R., 1984, Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid, Neurosci. Lett., 48: 273–278.
Germano, I.M., Pitts, L.H., Meldrum, B.S., Bartkowski, H.M., and Simon, R.P., 1987, Kynurenate inhibition of cell excitation decreases stroke size and deficits, Ann. Neurol., 22: 730–734.
Minatogawa, Y., Noguchi, T., and Kido, R., 1974, Kynurenine pyruvate trans-aminase in rat brain, J. Neurochem., 23: 271–272.
Noguchi, T., Minatogawa, Y., Okuno, E., Nakatani, M., Morimoto, M., and Kido, R., 1975, Purification and characterization of kynurenine-2-oxoglutarate aminotransferase from the liver, brain and small intestine of rats, Biochem. J., 151: 399–406.
Noguchi, T., and Kido, R., 1976, Identity of kynurenine:pyruvate aminotrans-ferase with histidine:pyruvate aminotransferase, Hoppe-Seyler’s Z. Physiol. Chem., 357: 649–656.
Okuno, E., Köhler, C., and Schwarcz, R., 1987, Rat 3-hydroxyanthranilic acid oxygenase: purification from the liver and immunocytochemical localization in the brain, J. Neurochem., 49: 771–780.
Okuno, E., Minatogawa, Y., Nakamura, M., Kamoda, N., Nakanishi, J., Makino, M., and Kido, R., 1980, Crystallization and characterization of human liver kynurenine-glyoxylate aminotransferase, Biochem. J., 189: 581–590.
Simon, R.P., Young, R.S.K., Stont, S., and Cheng, S., 1986, Inhibition of excitatory neurotransmission with kynurenate reduces brain edema in neonatal anoxia, Neurosci. Lett., 71: 361–364.
Tobes, M.C., and Mason, M., 1975, L-kynurenine aminotransferase and L-α-aminoadipate aminotransferase, Biochem. Biophys. Res. Commun., 62: 390–397.
Tobes, M.C., and Mason, M., 1977, α-Aminoadipate aminotransferase and kynurenine aminotransferase: purification, characterization and further evidence for identity, J. Biol. Chem., 252: 4591–4599.
Towbin, H., Staehlin, T., and Gordon, J., 1979, Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sects: procedure and some applications, Proc. Nat. Acad. Sci. USA, 76: 4350–4354.
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© 1991 Plenum Press, New York
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Ishikawa, T., Okuno, E., Tsujimoto, M., Nakamura, M., Kido, R. (1991). Kynurenine-Pyruvate Aminotransferase in Rat Kidney and Brain. In: Schwarcz, R., Young, S.N., Brown, R.R. (eds) Kynurenine and Serotonin Pathways. Advances in Experimental Medicine and Biology, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5952-4_68
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DOI: https://doi.org/10.1007/978-1-4684-5952-4_68
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