Abstract
The catabolism of L-tryptophan through the kynurenine pathway has long been recognized as the predominant route for systemic L-tryptophan metabolism and synthesis of nicotinamide containing nucleotides in mammalian species (see Bender et al., 1982). The potential importance of this pathway in brain is highlighted by the fact that many intermediates and products of the kynurenine pathway, including quinolinic acid (QUIN), are neuroactive (Lapin, 1982; Perkins and Stone, 1983; Schwarcz et al., 1983).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bender, D.A., 1982, Biochemistry of tryptophan in health and disease, Mol. Aspects Med., 6: 101–197.
Foster, A.C., White, R.J., and Schwarcz, R., 1986, Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro. J. Neurochem., 47: 23–30.
Heyes, M.P., Hutto, B., and Markey, S.P., 1988, 4-Chloro-3-hydroxyanthranilic acid inhibits 3-hydroxyanthranilic acid oxidase in brain, Neurochem. Int., 13: 405.
Heyes, M.P., and Markey, S.P., 1988a, [18O]Quinolinic acid: its esterifica-tion without back exchange for use as internal standard in the quantification of brain and CSF quinolinic acid, Biomed. Environ. Mass Spectrom., 15: 291–293.
Heyes, M.P., and Markey, S.P., 1988b, Quantification of quinolinic acid in rat brain, whole blood and serum by gas chromatography and negative chemical ionization mass spectrometry: effects of systemic L-tryptophan administration on brain and blood quinolinic acid concentrations, Anal. Biochem., 174: 349–359.
Lapin, I.P., 1982, Convulsant action of intracerebroventricularly administered L-kynurenine sulphate, quinolinic acid and other derivatives of succinic acid, and effects of amino acids: structure-activity relationships, Neuropharmacology, 21: 1227–1233.
Okuno, E., Köhler, C., and Schwarcz, R., 1987, Rat 3-hydroxyanthranilic acid oxygenase: purification from the liver and immunocytochemical localization in the brain. J. Neurochem., 49: 771–780.
Parli, C.J., Krieter, P., and Schmidt, B., 1980, Metabolism of 6-chloro-tryptophan to 4-chloro-3-hydroxyanthranilic acid: a potent inhibitor of 3-hydroxyanthranilic acid oxidase, Arch. Biochem. Biophys., 203: 161–166.
Perkins, M.N., and Stone, T.W., 1983, Pharmacology and regional variations of quinolinic acid evoked excitations in rat central nervous system, J. Pharmacol. Exp. Ther., 226: 551–557.
Schwarcz, R., Whetsell, W.O., and Mangano, R.M., 1983, Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain, Science, 219: 316–318.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Plenum Press, New York
About this chapter
Cite this chapter
Ji, XD., Nishimura, M., Heyes, M.P. (1991). Non-Competitive Inhibition of 3-Hydroxyanthranilate-3, 4-Dioxygenase by 4-Chloro-3-Hydroxyanthranilic Acid in Whole Brain of Rat. In: Schwarcz, R., Young, S.N., Brown, R.R. (eds) Kynurenine and Serotonin Pathways. Advances in Experimental Medicine and Biology, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5952-4_67
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5952-4_67
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5954-8
Online ISBN: 978-1-4684-5952-4
eBook Packages: Springer Book Archive