Abstract
Common wisdom presently suggests that the neurobiological basis for therapies of sleep disorders with oral loading doses of L-tryptophan (TRP) is the increase in synthesis, storage and/or release of serotonin (5-HT) in syn-aptosomal compartments from TRP transported from plasma to central neurons. Quantitatively, the conversion of TRP to 5-HT and/or biologically active in-dole derivatives in brain structures is very small compared to tryptophan oxidation in the periphery through both dioxygenases (indole 2, 3-dioxygenase in lung, intestine and other organs and liver tryptophan 2, 3-dioxygenase). Therefore, the elucidation of strategies leading to an increased transport of the administered TRP dose into the brain and thus utilization within neurons is of considerable importance.
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References
Bender, D.A., and Totoe, L., 1984, High doses of vitamin B6 in the rat are associated with inhibition of hepatic tryptophan metabolism and increased uptake of tryptophan into the brain, J. Neurochem., 43: 733–736.
Green, A., and Aronson, J.K., 1983, The pharmakokinetics of oral L-trypto-phan; effects of dose and concomitant pyridoxine, allopurinol or nicotina-mide administration, in: “Management of Depression with Monoamine Precursors”, Van Praag, M.H., and Mendlewicz, J., eds., Adv. Biol. Psychiat., Vol. 10, Karger, Basel, pp. 67–81.
Hull, C.H., and Nie, N.H., 1981, SPSS update 7-9, McGraw-Hill, New York.
Joseph, M.H., and Risby, D., 1975, The determination of kynurenine in plasma, Clin. Chim. Acta, 63: 197–204.
Møller, S.E., 1981, Pharmacokinetics of tryptophan, renal handling of kynurenine and the effect of nicotinamide on its appearance in plasma and urine following L-tryptophan loading in healthy subjects, Eur. J. Clin. Pharmacol., 21: 137–142.
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© 1991 Plenum Press, New York
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Demisch, L., Kaczmarczyk, P. (1991). Tryptophan Metabolism in Healthy Subjects: Influence of Pyridoxine after Single or Repeated Administrations. In: Schwarcz, R., Young, S.N., Brown, R.R. (eds) Kynurenine and Serotonin Pathways. Advances in Experimental Medicine and Biology, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5952-4_58
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DOI: https://doi.org/10.1007/978-1-4684-5952-4_58
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