Abstract
Changes in the levels of certain regulatory enzymes and their indue-ibility by several hormones might account for the deterioration of physiological efficiency during aging in animals. Such changes may be brought about by the alterations in the template activity of their corresponding genes (Kanungo, 1975). Tryptophan pyrrolase (TP; L-tryptophan-oxygen 2, 3-oxidoreductase, E.C. 1.13.11.11) is a liver cytosolic enzyme that catalyzes the first and rate-limiting step in the degradation of tryptophan (Knox and Mehler, 1950), resulting in the synthesis of nicotinamide cofactors (Nish-izuka and Hayaishi, 1963). The present paper describes the activity and induction pattern of liver TP by estradiol and hydrocortisone in rats of different ages to elucidate molecular mechanisms of aging.
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References
Kanungo, M.S., 1975, A model for aging, J. Theor. Biol., 53: 253–261.
Kanungo, M.S., Patnaik, S.K., and Koul, O., 1975, Decrease in 17-beta-estra-diol receptor in brain of aging rats, Nature, 253: 366–367.
Knox, W.E., and Mehler, A.H., 1950, The conversion of tryptophan to kynur-enine in liver: the coupled tryptophan peroxidase system forming formyl-kynurenine, J. Biol. Chem., 187: 419–430.
Knox, W.E., Yip, A., and Reshef, L., 1970, L-tryptophan 2, 3-di-oxygenase (tryptophan pyrrolase) (rat liver), Meth. Enzymol., 17a: 415–421.
Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J., 1951, Protein estimation with Folin-Ciocalteau reagent, J. Biol. Chem., 193: 265–275.
Nishizuka Y., and Hayaishi, O., 1963, Studies on the biosynthesis of nico-tinamide adenine dinucleotide: enzymatic synthesis of niacin ribonucleo-tides from 3-hydroxyanthranilic acid in mammalian tissues, J. Biol. Chem., 238: 3369–3377.
Patnaik, S.K., 1979, Changes in the sub-types of soluble alanine aminotrans-ferase in the liver of rats during development and aging, Cell Biol. Int. Rep., 7: 607–614.
Patnaik, S.K., 1989, Evidence for estradiol induced differential expression of genes for brain RNA polymerase during developmental stages of the rat, Biochem. Int., 18: 721–728.
Patnaik, S.K., and Patnaik, R., 1989, Tissue-specific differential induction of arginase and ornithine aminotransferase by hydrocortisone during various developmental stages of the rat, Biochem. Int., 18: 709–719.
Patnaik, R., Sarangi, S.K., and Patnaik, S.K., 1987a, Tissue-specific differential induction of ornithine aminotransferase by estradiol in rats of various ages, Biochem. Int., 14: 843–850.
Patnaik, S.K., Sharma, R., and Patnaik, R., 1987b, Differential effects of hydrocortisone on aspartate aminotransferase isozymes of the liver of rats during growth, development, and senescence, Biochem. Int., 15: 611–617.
Roth, G.S., and Adelman, R.C., 1974, Age-dependent regulation of mammalian DNA synthesis and cell division in vivo by glucocorticoids, Exp. Gerontol., 9: 27–31.
Roth, G.S., and Adelman, R.C., 1975, Age-related changes in hormone binding by target cells and tissues, possible role in altered adaptive responsiveness, Exp. Gerontol., 10: 1–11.
Sharma, R., and Patnaik, S.K., 1983, Induction of phosphoenolpyruvate carbo-xykinase by hydrocortisone in rat liver and brain as a function of age, Biochem. Int., 7: 535–540.
Sharma, R., and Patnaik, S.K., 1984, Age-related response of citrate synthase to hydrocortisone in the liver and brain of male rats, Experientia, 40: 97–98.
Sharma, R., and Patnaik, S.K., 1985, Age-dependent regulation of aspartate aminotransferase isozymes by hydrocortisone in the brain of male rats, Mol. Physiol., 7: 195–200.
Singer, S., Ito, H., and Litwack, G., 1973, 3H-Cortisol binding by young and old human liver cytosol protein in vitro. Int. J. Biochem., 4: 569–573.
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© 1991 Plenum Press, New York
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Patnaik, S.K. (1991). Differential Effects of Estradiol and Hydrocortisone on Liver Tryptophan Pyrrolase in Rats of Various Ages. In: Schwarcz, R., Young, S.N., Brown, R.R. (eds) Kynurenine and Serotonin Pathways. Advances in Experimental Medicine and Biology, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5952-4_56
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DOI: https://doi.org/10.1007/978-1-4684-5952-4_56
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