Abstract
A relative excess of leucine in dietary proteins has been implicated in the etiology of the tryptophan-niacin deficiency disease pellagra in those parts of India where the dietary staple is jowar (Sorghum vulgare) (Gopalan and Srikantia, 1960).
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References
Bender, D.A., 1983, Effects of a dietary excess of leucine on the metabolism of tryptophan in the rat: a mechanism for the pellagragenic action of leucine, Br. J. Nutr., 50: 25–32.
Gopalan, C., and Srikantia, S.G., 1960, Leucine and pellagra, Lancet, 1: 954–957.
Magboul, B.I., and Bender, D.A., 1983, Effects of a dietary excess of leucine on the synthesis of nicotinamide nucleotides in the rat, Br. J. Nutr., 49: 321–329.
Salter, M., Bender, D.A., and Pogson, C.I., 1985, Leucine and tryptophan metabolism in rats, Biochem. J., 225: 277–281.
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© 1991 Plenum Press, New York
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Bender, D.A. (1991). Inhibition of Tryptophan → Niacin Metabolism by Dietary Leucine and by Leucine and 2-Oxo-isocaproate in vitro. In: Schwarcz, R., Young, S.N., Brown, R.R. (eds) Kynurenine and Serotonin Pathways. Advances in Experimental Medicine and Biology, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5952-4_54
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DOI: https://doi.org/10.1007/978-1-4684-5952-4_54
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