Signal-to-Noise Optimization of HPLC-Fluorometric Systems and their Application to the Analysis of Indoles

  • G. M. Anderson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)


The signal-to-noise optimization of high performance liquid Chromatographic (HPLC) flow-cell fluorometric systems is described and the possibilities for further improving limits of detection for indoles is discussed. Application of HPLC-fluorometry to analyses in rat cerebrospinal fluid (CSF), human lumbar CSF, and human blood is presented. Finally, the intriguing clinical finding of hyperserotonemia in autism is discussed.


High Performance Liquid Chromato Source Intensity Autistic Subject High Performance Liquid Chromato High Performance Liquid Chromato 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • G. M. Anderson
    • 1
  1. 1.Child Study Center and Department of Laboratory MedicineYale University School of MedicineNew HavenUSA

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