The Excretion of N1-Methyl-2-Pyridone-5-Carboxylic Acid and Related Compounds in Human Subjects after Oral Administration of Nicotinic Acid, Trigonalline and N1-Methyl-2-Pyridone-5-Carboxylic Acid

Yuyama, S.; Suzuki, T.

doi:10.1007/978-1-4684-5952-4_48

S. Yuyama⁴ &
T. Suzuki⁴

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 294))

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Abstract

During the development of a procedure for the determination of trigonel-line (Tg) in human urine (Yuyama and Suzuki, 1987), an organic acid with a similar ultra-violet spectrum was isolated. The compound was found to be N¹-methyl-2-pyridone-5-carboxylic acid (Tg-2Py) (Lindenblad et al., 1956), which Holman et al. (1950) were unable to detect in normal human urine. In the present study, Tg-2Py was determined by HPTLC. The urinary excretion of Tg-2Py, Tg and N¹-methylnicotinamide (MNA) were determined before and after the oral administration of nicotinic acid (NiA), Tg and Tg-2Py.

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References

Holman, W.I.M., and Lange, D.J., 1950, Metabolism of nicotinic acid and related compounds by humans, Nature, 165: 604–605.
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Lindenblad, G.E., Kaihara, M., and Price, J.M., 1956, The occurrence of N-methyl-2-pyridone-5-carboxylic acid and its glycine conjugate in normal human urine, J. Biol. Chem., 219: 893–901.
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Yuyama, S., and Suzuki, T., 1987, Urinary excretion of trigonelline and N¹-methylnicotinamide by human beings and rats following oral administration of nicotinic acid or trigonelline, in: “Progress in Tryptophan and Serotonin Research”, Bender, D.A., Joseph, M.H., Kochen, W., and Steinhart H., eds., de Gruyter, Berlin, pp. 197–202.
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Department of Nutrition and Biochemistry, The Institute of Public Health, Tokyo 108, Japan
S. Yuyama & T. Suzuki

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S. Yuyama
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T. Suzuki
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Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA
Robert Schwarcz
McGill University, Montreal, Quebec, Canada
Simon N. Young
University of Wisconsin, Madison, Wisconsin, USA
Raymond R. Brown

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Yuyama, S., Suzuki, T. (1991). The Excretion of N¹-Methyl-2-Pyridone-5-Carboxylic Acid and Related Compounds in Human Subjects after Oral Administration of Nicotinic Acid, Trigonalline and N¹-Methyl-2-Pyridone-5-Carboxylic Acid. In: Schwarcz, R., Young, S.N., Brown, R.R. (eds) Kynurenine and Serotonin Pathways. Advances in Experimental Medicine and Biology, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5952-4_48

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DOI: https://doi.org/10.1007/978-1-4684-5952-4_48
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5954-8
Online ISBN: 978-1-4684-5952-4
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