Induction of Indoleamine 2,3-Dioxygenase in Tumor Cells Transplanted into Allogeneic Mouse: Interferon-γ is the Inducer

  • O. Takikawa
  • A. Habara-Ohkubo
  • R. Yoshida
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)


The major catabolic pathway of tryptophan in mammals is the kynurenine pathway. In adult young man in fact about 90% of dietary tryptophan is metabolized along this pathway (Fig. 1) (Wolf, 1974). Although it has long been generally accepted that “hepatic” L-tryptophan 2,3-dioxygenase (tryptophan pyrrolase) is the sole enzyme that catalyzes the first step of this pathway, recent studies have revealed that another enzyme called indoleamine 2,3-dioxygenase (IDO), which catalyzes the same reaction as “hepatic” enzyme, does occur in various “extra-hepatic” organs of mammals [mouse (Yoshida et al., 1980; Yoshida et al., 1981), rat (Cook et al., 1980), rabbit (Hayaishi et al., 1975 and human (Yamazaki et al., 1985)].


Conditioned Medium Chlamydia Trachomatis Kynurenic Acid Kynurenine Pathway Tryptophan Depletion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • O. Takikawa
    • 1
  • A. Habara-Ohkubo
    • 1
  • R. Yoshida
    • 1
  1. 1.Department of Cell BiologyOsaka Bioscience InstituteOsaka 565Japan

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