The Role of Serotonin (5-HT) in Feeding Responses to Amino Acids

  • D. W. Gietzen
  • V. A. Hammer
  • J. L. Beverly
  • Q. R. Rogers
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)


A model of rapid onset anorexia has emerged from nutritional, biochemical and neurophysiological studies over the past 30 years, in which rats are fed diets containing imbalanced proportions of amino acids (Harper et al., 1970; Rogers and Leung, 1977; Gietzen et al., 1986a). The neurochemical changes engendered by ingestion of these diets are now beginning to be elucidated. In this model, the limiting amino acid is decreased in several brain areas, and both the noradrenergic and serotonergic systems appear to be activated as the animals begin to decrease their intake of the imbalanced diet. The studies presented here suggest a role for serotonin (5-HT), via a specific receptor subtype, the 5-HT3 receptor, in the initial anorectic response of rats to imbalanced amino acid diets.


Basal Diet Limit Amino Acid Postsynaptic Site Feeding Response Amino Acid Imbalance 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • D. W. Gietzen
    • 1
  • V. A. Hammer
    • 1
  • J. L. Beverly
    • 1
  • Q. R. Rogers
    • 1
  1. 1.Departments of Physiological Sciences and Psychiatry and Food Intake LaboratoryUniversity of CaliforniaDavisUSA

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