Abstract
A model of rapid onset anorexia has emerged from nutritional, biochemical and neurophysiological studies over the past 30 years, in which rats are fed diets containing imbalanced proportions of amino acids (Harper et al., 1970; Rogers and Leung, 1977; Gietzen et al., 1986a). The neurochemical changes engendered by ingestion of these diets are now beginning to be elucidated. In this model, the limiting amino acid is decreased in several brain areas, and both the noradrenergic and serotonergic systems appear to be activated as the animals begin to decrease their intake of the imbalanced diet. The studies presented here suggest a role for serotonin (5-HT), via a specific receptor subtype, the 5-HT3 receptor, in the initial anorectic response of rats to imbalanced amino acid diets.
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References
Baumgarten, H.G., and Lachenmayer, L., 1977, Chemically induced degeneration of the indoleamine-containing nerve terminals in rat brain, Brain Res., 38: 228–232.
Beverly, J.L., Gietzen, D.W., Leung, P.M.B., and Rogers, Q.R., 1988, Threonine (Thr) injection into the prepyriform cortex increases the intake of thr imbalanced diet, Soc. Neurosci. Abstr., 14: 215.6.
Blundell, J.E., 1984a, Serotonin and appetite, Neuropharmacology, 23: 1537–1551.
Blundell, J.E., 1984b, Systems and interactions, an approach to the pharmacology of eating and hunger, in: “Eating and its Disorders”, Stunkard A.J., and Stellar, E., eds., Raven Press, New York, pp. 39–65.
Bradley, P.B., Engel, G., Feniuk, W., Fozard, J.R., Humphrey, P.P.A., Middlemiss, D.N., Mylecharane, E.J., Richardson, B.P., and Saxena, P.R., 1986, Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine, Neuropharmacology, 25: 563–576.
Chaouloff, F., and Jean Renaud, B., 1987, 5-HT1A and alpha2 adrenergic receptors mediate the hyperglycemie and hypoinsulinemic effects of 8-hydroxy-2-(di-n-propylamino)tetralin in the conscious rat, J. Pharmacol. Exp. Therap., 243: 1159–1166.
Colpaert, F.C., and Janssen, P.A.J., 1983, The head-twitch response to intraperitoneal injection of 5-hydroxytryptophan in the rat: antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenpirone, an LSD antagonist, Neuropharmacology, 22: 993–1000.
Cooper, S.J., 1987, Palatability-induced food consumption is stimulated by 8-hydroxy-2-di-n-propylaminotetralin (8-OH-DPAT) in: “Brain 5-HT 1A Receptors”, Dourish, C.T., Ahlenius, S., and Hutson, P.H., eds., Ellis Horwood Ltd., Chichester, England, pp. 233–242.
Costall, B., Domeney, A.M., Naylor, R.J., and Tattersall, J.D., 1987, Emesis induced by cisplatin in the ferret as a model for the detection of antiemetic drugs, Neuropharmacology, 26: 1321–1326.
Costall, B., Gunning, S.J., and Naylor, R.J., 1985, An analysis of the hypothalamic sites at which substituted benzamide drugs act to facilitate gastric emptying in the guinea pig, Neuropharmacology, 24: 869–875.
Costall, B., Naylor, R.J., and Tyers, M.B., 1988, Recent advances in the neuropharmacology of 5-HT3 agonists and antagonists, Rev. Neurosci., 2: 41–65.
Dourish, C.T., Ahlenius, S., and Hutson, P.H., 1987, Classification and summary tables, in: “Brain 5-HT 1A Receptors, Behavior and Neurochemical Pharmacology”, Dourish, C.T., Ahlenius, S., and Hutson, P.H., eds., Ellis Horwood Ltd., Chichester, England, pp. 11–12.
Dourish, C.T., Hutson, P.H., Kennett, G.A., and Curzon, G., 1986, 8-OH-DPAT-induced hyperphagia: its neural basis and possible therapeutic relevance, Appetite, Suppl., 7: 127–140.
Engel, G., Gothert, M.K., Hoyer, D., Schlicker, E., and Hillenbrand, K., 1986, Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites, NaunynSchmiedeberg’s Arch. Pharmacol., 357: 1–7.
Fuller, R.W., 1985, Drugs altering serotonin synthesis and metabolism, in: “Neuropharmacology of Serotonin”, Green, A.R., ed., Oxford University Press, New York, pp. 1–20.
Garattini, S., Mennini, T., Bendotti, C., Invernizzi, R., and Samanin, R., 1986, Neurochemical mechanism of action of drugs which modify feeding via the serotonergic system, Appetite, Suppl., 7: 15–38.
Gietzen, D.W., Leung, P.M.B., Castonguay, T.W., Hartman, W.J., and Rogers, Q.R., 1986a, Time course of food intake and plasma and brain amino acid concentrations in rats fed amino acid-imbalanced or deficient diets, in: “Interaction of the Chemical Senses with Nutrition”, Kare, M.R., and Brand, J.C, eds., Academic Press, New York, pp. 415–456.
Gietzen, D.W., Leung, P.M.B., and Rogers, Q.R., 1986b, Norepinephrine and amino acids in prepyriform cortex of rats fed amino acid-imbalanced diets, Physiol. Behav., 36: 1071–1080.
Gietzen, D.W., Rogers, Q.R., Leung, P.M.B., Semon, B., and Piechota, T., 1987, Serotonin and feeding responses of rats to amino acid imbalance: the initial phase, Am. J. Phsyiol., 253: R763–R771.
Hammer, V.A., Gietzen, D.W., Beverly, J.L., Sworts, V.D., and Rogers, Q.R., 1990, The role of adrenal hormones in the initial feeding response and adaptation of rats to amino acid imbalance, J. Nutr., in press.
Harper, A.E., Benevenga, N.J., and Wohlheuter, R.M., 1970, Effects of ingestion of disportionate amounts of amino acids, Physiol. Rev., 50: 428–558.
Hutson, P.H., Dourish, C.T., and Curzon, G., 1987, 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)-induced hyperphagia: neurochemical and pharmacological evidence for an involvement of 5-hydroxytryptamine somatodendritic autoreceptors, in: “Brain 5-HT 1A Receptors”, Dourish, C.T., Ahlenius, S., and Hutson, P.H., eds., Ellis Horwood Ltd., Chichester, England, pp. 211–232.
Joyce, D., and Mrosovsky, N., 1964, Eating, drinking and activity in rats following 5-hydroxytryptophan (5-HTP) administration, Psychopharmacologia, 5: 417–423.
Kennett, G.A., Dourish, C.T., and Curzon, G., 1987, 5HT1B agonists induce anorexia at a postsynaptic site, Eur. J. Pharmacol., 141: 429–435.
Kilpatrick, G.J., Jones, B.J., and Tyers, M.B., 1987, Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding, Nature, 330: 746–748.
Koe, B.K., and Weissman, A., 1966, p-Chlorophenylalanine: a specific depletor of brain serotonin, J. Pharmacol. Exp. Therap., 154: 499–516.
Lakoski, J.M., and Aghajanian, G.K., 1985, Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus, Neuropharmacology, 24: 265–273.
Leung, P.M.B., Larson, D.M., and Rogers, Q.R., 1972, Food intake and preference of olfactory bulbectomized rats fed amino acid imbalanced or deficient diets, Physiol. Behav., 9: 553–557.
Leung, P.M.B., and Rogers, Q.R., 1969, Food intake: regulation by plasma amino acid pattern, Life Sci., 8: 1–9.
Leung, P.M.B., and Rogers, Q.R., 1970, Effect of amino acid imbalance and deficiency on food intake of rats with hypothalamic lesions, Nutr. Rep. Intl., 1: 1–10.
Leung, P.M.B., and Rogers, Q.R., 1987, The effect of amino acids and protein on dietary choice, in: “Umami: A Basic Taste”, Kawamura, Y., and Kare, M.R., eds., Marcel Dekker, New York, pp. 565–610.
Leung, P.M.B., Rogers, Q.R., and Harper, A.E., 1968, Effect of cortisol on growth, food intake, dietary preferences and plasma amino acid pattern of rats fed amino acid imbalanced diets, J. Nutr., 96: 139–151.
Leysen, J.E., 1985, Characterization of serotonin receptor binding sites, in: “Neuropharmacology of Serotonin”, Green, A.R., ed., Oxford University Press, New York, pp. 76–116.
Massi, M., and Marini, S., 1987, Effect of the 5HT2 antagonist ritanserin on food intake and on 5HT-induced anorexia in the rat, Pharmacol. Biochem. Behav., 26: 333–340.
Peroutka, S.J., 1988, 5-Hydroxytryptamine receptor subtypes: molecular, biochemical and physiological characterization, Trends Neurosci., 11: 496–500.
Peroutka, S.J., and Hamik, A., 1988, [3H] Quipazine labels 5-HT3 recognition sites in rat cortical membranes, Eur. J. Pharmacol., 148: 297–299.
Peroutka, S.J., Lebovitz, R.M., and Snyder, S.H., 1981, Two distinct central serotonin receptors with different physiological functions, Science, 212: 827–829.
Peters, J.C., Bellissimo, D.B., and Harper, A.E., 1984, L-Tryptophan injection fails to alter nutrient selection by rats, Physiol. Behav., 32: 253–259.
Richardson, B.P., and Engel, C., 1986, The pharmacology and function of 5-HT3 receptors, Trends Neurosci., 7: 424–428.
Rogers, Q.R., and Leung, P.M.B., 1977, The control of food intake: when and how are amino acids involved, in: “The Chemical Senses and Nutrition”, Kare, M.R., and Mailer, O., eds., Academic Press, New York, pp. 213–249.
Schechter, L.E., and Simansky, K.J., 1988, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) exerts an anorectic action that is blocked by 5-HT2 antagonists in rats, Psychopharmacology, 94: 342–346.
Smith, G.P., and Schneider, L.H., 1988, Relationships between mesolimbic dopamine function and eating behavior, Annal. N.Y. Acad. Sci., 537: 254–261.
Stickney, G.D., Leung, P.M.B., Rogers, Q.R., Lepkovsky, S., and Schmidt, P., 1976, The effect of total gastrectomy on free feeding patterns in rats, Fed. Proc, 35:Abstr. 520.
Tobin, G., and Boorman, K.N., 1979, Carotid or jugular amino acid infusion and food intake in the cockerel, Br. J. Nutr., 41: 157–162.
Willcock, E.G., and Hopkins, F.G., 1906, The importance of individual amino acids in metabolism; observations on the effect of adding tryptophane to a dietary in which zein is the sole nitrogenous constituent, J. Physiol., 35: 88–102.
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© 1991 Plenum Press, New York
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Gietzen, D.W., Hammer, V.A., Beverly, J.L., Rogers, Q.R. (1991). The Role of Serotonin (5-HT) in Feeding Responses to Amino Acids. In: Schwarcz, R., Young, S.N., Brown, R.R. (eds) Kynurenine and Serotonin Pathways. Advances in Experimental Medicine and Biology, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5952-4_36
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DOI: https://doi.org/10.1007/978-1-4684-5952-4_36
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