Behavioral Abnormalities in Rats after Single Treatment with Quinolinic Acid During Early Ontogenesis

  • I. P. Lapin
  • V. L. Kozlovsky
  • O. G. Kenunen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)


Neonatal brain injuries which occur under hypoxia, ischemia, hypoglycemia and trauma (Rothman and Olney, 1986; Simon et al., 1986; Ikonomidou et al., 1988; Mclntosh et al., 1988) have recently been suggested to be mediated through activation of excitatory amino acid systems. In particular, neurodestructive changes in the developing brain are thought to be due to stimulation of N-methyl-D-aspartate (NMDA) receptors (Simon et al., 1986; McDonald et al., 1988).


Excitatory Amino Acid Quinolinic Acid Behavioral Abnormality Dark Compartment Excitatory Amino Acid Receptor 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • I. P. Lapin
    • 1
  • V. L. Kozlovsky
    • 1
  • O. G. Kenunen
    • 1
  1. 1.Laboratory of PsychopharmacologyBekhterev Psychoneurological Research InstituteLeningradUSSR

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