Melatonin Interaction with the Benzodiazepine-GABA Receptor Complex in the CNS

  • L. Niles
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)


The major inhibitory neurotransmitter, γ-aminobutyric acid (GABA) acts on a postsynaptic receptor complex which includes GABA and benzodiazepine (BZ) recognition sites and a chloride ionophore (Turner and Whittle, 1983). Pharmacological, biochemical and neurophysiological studies suggest that BZ agonists, such as diazepam, exert their central effects by enhancing lowaffinity GABA binding (DeFeudis, 1983; Olsen and Venter, 1986).


Cortical Membrane Gaba Binding Diazepam Binding Diazepam Binding Inhibition Muscimol Binding 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • L. Niles
    • 1
  1. 1.Department of Biomedical Sciences Division of NeuroscienceMcMaster UniversityHamiltonCanada

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