Melatonin Receptors in the Central Nervous System

  • M. L. Dubocovich
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)


The hormone melatonin is synthesized primarily in the pineal gland of vertebrates from its precursor serotonin (5-hydroxytryptamine). Serotonin is N-acetylated by a relatively specific N-acetyltransferase to yield N-acetylserotonin, which in turn is methylated by hydroxyindole-O-methyltransferase to melatonin (5-methoxy-N-acetyltryptamine) (Axelrod, 1974).


Pineal Gland Dopamine Release Syrian Hamster Median Eminence Suprachiasmatic Nucleus 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • M. L. Dubocovich
    • 1
  1. 1.Department of PharmacologyNorthwestern University Medical SchoolChicagoUSA

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