Tryptophan and Related Alkaloids
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Tryptophan is metabolized to a number of biologically important substances (Hayaishi, 1962, 1974). It is now well established that tryptophan is metabolized to NAD via formylkynurenine which was formed by the oxidative cleavage of the 2,3-bond of the indole ring catalyzed by tryptophan-2,3-dioxygenase. On the other hand, the hydroxylation of tryptophan at 5-position accompanied by the NIH shift is another important reaction catalyzed by tryptophan 5-hydroxylase (Daly et al., 1972; Jerina and Daly, 1974; Boyd and Berchtold, 1979). Furthermore, tryptophan also serves as an important precursor for the biosynthesis of indole alkaloids (Scheme 1).
KeywordsMethylene Blue Total Synthesis Acridine Orange Indole Alkaloid Quinone Imine
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