Tryptophan and Related Alkaloids

  • M. Nakagawa
  • T. Hino
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)


Tryptophan is metabolized to a number of biologically important substances (Hayaishi, 1962, 1974). It is now well established that tryptophan is metabolized to NAD via formylkynurenine which was formed by the oxidative cleavage of the 2,3-bond of the indole ring catalyzed by tryptophan-2,3-dioxygenase. On the other hand, the hydroxylation of tryptophan at 5-position accompanied by the NIH shift is another important reaction catalyzed by tryptophan 5-hydroxylase (Daly et al., 1972; Jerina and Daly, 1974; Boyd and Berchtold, 1979). Furthermore, tryptophan also serves as an important precursor for the biosynthesis of indole alkaloids (Scheme 1).


Methylene Blue Total Synthesis Acridine Orange Indole Alkaloid Quinone Imine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • M. Nakagawa
    • 1
  • T. Hino
    • 1
  1. 1.Faculty of Pharmaceutical SciencesChiba UniversityJapan

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