Kynurenate Forming Enzymes in Liver, Kidney and Brain
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Kynurenate was discovered by Liebig in 1853. The name he chose for this compound is still appropriate, since it occurs in higher concentration in the urine of dogs and closely related species than in the urine of other animals (Gordon et al... 1936; Jackson, 1939; Brown and Price, 1956). The discovery of tryptophan by Hopkins and Cole (1901) was followed shortly by the observation (Ellinger, 1904) that kynurenate was a metabolite of this amino acid. By the time the conversion of tryptophan-14C to kynurenate-14C was demonstrated (Heidelberger et al., 1949), it came as no surprise. On the other hand, the Kotake school found that kynurenine was an intermediary metabolite of tryptophan (Kotake and Iwao, 1931) and a metabolic precursor of kynurenate (Kotake, 1931).
KeywordsQuinolinic Acid Aminotransferase Activity Kynurenic Acid Glyoxylic Acid Intermediary Metabolite
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- Gordon, W.G., Kaufman, R.E., and Jackson, R.W., 1936, The excretion of kynurenic acid by the mammalian organism. A method for the identification of small amounts of kynurenic acid, J. Biol. Chem., 113: 125–134.Google Scholar
- Jackson, R.W., 1939, The excretion of kynurenic acid by members of various families of the order Carnivora, J. Biol. Chem., 131: 469–478.Google Scholar
- Okuno, E., Minatogawa, Y., Nakamura, M., Kamoda, N., Nakanishi, J., Makino, M., and Kido, R., 1980, Crystallization and characterization of human liver kynurenine-glyoxylate aminotransferase: Identity with alanineglyoxylate aminotransferase and serine-pyruvate aminotransferase, Biochem. J., 189: 581–590.PubMedGoogle Scholar