The Role of Tryptophan and Kynurenine Transport in the Catabolism of Tryptophan Through Indoleamine 2,3-Dioxygenase
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In 1967, indoleamine 2,3-dioxygenase (IDO) was first reported as being an enzyme capable of cleaving the indole ring of tryptophan (Scheme 1), which was distinct from the tryptophan 2,3-dioxygenase (TDO) found in the liver (Yamamoto and Hayaishi, 1967). Later studies revealed its presence in a range of tissues in mice and rats (Cook et al., 1980; Yoshida et al., 1980), and more recently in man (Yamazaki et al., 1985).
KeywordsTryptophan Depletion Tryptophan Metabolism Tryptophan Concentration Tryptophan Catabolism WiDr Cell
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