Interrelationships of DNA Cycles and Melatonin Synthesis

  • S. D. Wainwright
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)


Both the chick and the rat pineal glands convert tryptophan to melatonin by the same pathway, outlined by Klein et al. (1981). In both cases, the rate-limiting step is the acetylation of serotonin by the enzyme serotonin N-acetyltransferase (NAT), described by Voisin et al. (1984). Further, the pineals of both species exhibit circadian rhythms in the production of melatonin and in the level of NAT activity.


Circadian Rhythm Pineal Gland Thymidine Incorporation Superior Cervical Ganglion Plasma Melatonin 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • S. D. Wainwright
    • 1
  1. 1.Biochemistry DepartmentDalhousie UniversityHalifaxCanada

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