Interrelationships of DNA Cycles and Melatonin Synthesis
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Both the chick and the rat pineal glands convert tryptophan to melatonin by the same pathway, outlined by Klein et al. (1981). In both cases, the rate-limiting step is the acetylation of serotonin by the enzyme serotonin N-acetyltransferase (NAT), described by Voisin et al. (1984). Further, the pineals of both species exhibit circadian rhythms in the production of melatonin and in the level of NAT activity.
KeywordsCircadian Rhythm Pineal Gland Thymidine Incorporation Superior Cervical Ganglion Plasma Melatonin
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