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Early Events in the Hormonal Regulation of Glial Gene Expression: Early Response Genes

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Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 293))

Abstract

Glial cells play important roles in the development arid the functioning of the brain (Arenander and de Vellis, 1983, Arenander and de Vellis, 1989). Glial cell development and functions are regulated by growth factors, hormones, neurotransmitters and other autocrine and paracrine factors and cell-cell contact. How are these factors mediating their effects? The diversity of cell types and complexity of cellular interaction necessitated developing in vitro methods to study mechanisms of glial growth and function. Cell culture techniques allow experimental control of developmental events and molecular markers allow precise identification of cell types. As a result, glial research has greatly advanced our understanding of the molecular and cellular mechanisms regulating neural development.

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Authors and Affiliations

  1. Department of Anatomy and Cell Biology, Mental Retardation Research Center, NPI, UCLA School of Medicine, Los Angeles, CA, USA

    Alaric Arenander, Janet Cheng & Jean de Vellis

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  1. Alaric Arenander
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  2. Janet Cheng
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  3. Jean de Vellis
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Editors and Affiliations

  1. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada

  2. National Institutes of Health, Bethesda, Maryland, USA

    Derek LeRoith

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Arenander, A., Cheng, J., de Vellis, J. (1991). Early Events in the Hormonal Regulation of Glial Gene Expression: Early Response Genes. In: Raizada, M.K., LeRoith, D. (eds) Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors. Advances in Experimental Medicine and Biology, vol 293. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5949-4_30

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