Abstract
We have prepared a series of IGF I analogs in order to determine the structural requirements for binding to the types 1 and 2 IGF receptors and to IGF binding proteins (1-5). These analogs were designed by substituting regions of IGF I with analogous regions of insulin, by deleting or replacing regions of IGF I that are absent in insulin, or by replacing specific residues of IGF I. The binding data for these analogs is summarized in Table 1.
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© 1991 Plenum Press, New York
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Cascieri, M.A., Chicchi, G.G., Bayne, M.L. (1991). Characterization of the Biological Activity of IGF I Analogs with Reduced Affinity for IGF Receptors and Binding Proteins. In: Raizada, M.K., LeRoith, D. (eds) Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors. Advances in Experimental Medicine and Biology, vol 293. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5949-4_3
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DOI: https://doi.org/10.1007/978-1-4684-5949-4_3
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