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Regulation of Gene Expression of Rat Insulin-Like Growth Factor Binding Proteins 1 and 2

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Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 293))

Abstract

Virtually all of the insulin-like growth factors (IGFs) in extracellular fluids and cell culture medium occur complexed to specific IGF-binding proteins (IGFBPs).1,2 The IGFBPs are a family of proteins that bind IGF-I and IGF-II but are unrelated to IGF receptors. Four IGFBPs have been cloned from human and rat sources,1–8 and partial protein sequence information is available forafifthlGFBP.9–11 OthermembersoftheIGFBPfamilyundoubtedlyexist,12butspecific assignment must await amino acid or nucleotide sequencing.

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Author information

Authors and Affiliations

  1. Growth and Development Section, Molecular, Cellular and Nutritional Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Matthew M. Rechler, Alexandra L. Brown, Guck T. Ooi, Craig C. Orlowski, Lucy Y.-H. Tseng & Yvonne W.-H. Yang

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  1. Matthew M. Rechler
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  2. Alexandra L. Brown
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  3. Guck T. Ooi
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  4. Craig C. Orlowski
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  5. Lucy Y.-H. Tseng
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  6. Yvonne W.-H. Yang
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Editors and Affiliations

  1. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada

  2. National Institutes of Health, Bethesda, Maryland, USA

    Derek LeRoith

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© 1991 Plenum Press, New York

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Rechler, M.M., Brown, A.L., Ooi, G.T., Orlowski, C.C., Tseng, L.YH., Yang, Y.WH. (1991). Regulation of Gene Expression of Rat Insulin-Like Growth Factor Binding Proteins 1 and 2. In: Raizada, M.K., LeRoith, D. (eds) Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors. Advances in Experimental Medicine and Biology, vol 293. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5949-4_13

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  • DOI: https://doi.org/10.1007/978-1-4684-5949-4_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5951-7

  • Online ISBN: 978-1-4684-5949-4

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