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Regulation and Actions of Insulin-Like Growth Factor Binding Protein-3

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Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 293))

Abstract

Binding proteins for the insulin-like growth factors (IGFs), first described 15 years ago, are now recognized as playing important roles as carriers of IGFs in the circulation, and modulators of IGF actions on target cells 1. Three distinct structural classes of IGF binding protein (IGFBP) have been identified on the basis of cDNA cloning 2–6, and at least two other structurally distinct proteins appear to exist 7–9. The predominant circulating IGFBP is an acid-stable glycoprotein with the systematic name IGFBP-3 . This paper will discuss recent studies, mainly from the authors’ laboratory, which relate to the dual roles of IGFBP-3, as part of the growth hormone (GH) dependent, high molecular weight ternary IGF complex in serum, and as local cell regulators of mitogenic actions of the IGFs.

This work was supported by the National Health & Medical Research Council, Australia

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Authors and Affiliations

  1. Endocrinology Department, Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia

    Robert C. Baxter & Janet L. Martin

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  1. Robert C. Baxter
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  2. Janet L. Martin
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Editors and Affiliations

  1. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada

  2. National Institutes of Health, Bethesda, Maryland, USA

    Derek LeRoith

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© 1991 Plenum Press, New York

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Baxter, R.C., Martin, J.L. (1991). Regulation and Actions of Insulin-Like Growth Factor Binding Protein-3. In: Raizada, M.K., LeRoith, D. (eds) Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors. Advances in Experimental Medicine and Biology, vol 293. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5949-4_12

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  • DOI: https://doi.org/10.1007/978-1-4684-5949-4_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5951-7

  • Online ISBN: 978-1-4684-5949-4

  • eBook Packages: Springer Book Archive

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