Abstract
This book is based on the proceedings of the NATO Advanced Study Institute (ASI) on ‘The Molecular Pathology of Alcoholism’ held at Il Ciocco in Italy on August 26th -September 6th 1990. An important part of this ASI was a one-day Workshop organised by Jean-Pierre von Wartburg on the theme ‘Future Directions in Biomedical Research in Alcoholism’. The purpose of this Workshop was to allow a few distinguished researchers in the field of alcoholism to informally muse on the directions that future research in this important area may take. Selected contributions to this Workshop are included in this volume.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Best, C. H., Hartroft, W. S., Lucas, C.C. and Ridout, J. H., 1949, Liver damage produced by feeding alcohol or sugar and its prevention by choline, Brit. Med. J., 2: 1001.
Blass, J. P., and Gibson, G.E., 1977, Abnormality of a thiamine-requiring enzyme in patients with Wernicke-Korsakoff syndrome, New Engl. J. Med., 297: 1367.
Blum, K., Noble, E. P., Sheridan, P. J., Montgomery, A., Ritchie, T., Jagadeeswaram, P.,Nogami, H., Briggs, A. H., Cohn, A. H., and Cohn, J.B., 1990, Allelic association of human dopamine D2 receptor gene in alcoholism, JAMA., 263: 2055.
Goedde, H. W., Agarwal, D. P., Eckey, R., and Harada, S., 1985, Population genetic and family studies on aldehyde dehydrogenase deficiency and alcohol sensitivity, Alcohol, 2: 283.
Gonzalez, F. J., Skoda, R. C., Kimura, S., Umeno, M., Zanger, U. M., Neben, D. W., Gelboin,H. V., Hardwick, J. P., and Meyer, U. A., 1988, Characterization of the common genetic defect in humans deficient in debrisoquine metabolism, Nature, 331: 442.
Karl, P. I., Gordon, B. H. J., Lieber, C. S., and Fisher, S. E., 1988, Acetaldehyde production and transfer by the perfused human placental cotyledon, Science, 242: 273.
Lieber, C. S., 1982a, in: Medical Disorders of Alcoholism: Pathogenesis and Treatment, C.S.Lieber, ed., WB Saunders, Philadelphia, PA.
Lieber, C. S., 1982b, A public health approach for the control of the disease of alcoholism, Alcoholism: Clin. Exp. Res., 6: 171.
Lieber, C. S., 1985, Early detection of precursor lesions of liver cirrhosis, in: Early Identification of Alcohol Abuse, N. Chang, and H. M. Chao, eds., Research Monograph-17, DHHS Publication No. (ADM) 85–1285, Superintendent of Documents, US Government Printing Office, Washington DC, pp. 168.
Lieber, C. S., 1988a, Biochemical and molecular basis for alcohol-induced injury to liver and other tissues. New Engl. J. Med., 319: 16–39.
Lieber, C. S., 1988b, The influence of alcohol on nutritional status, Nutr. Rev., 46: 241.
Lieber, C. S., 1988c, Metabolic effects of acetaldehyde, Biochem. Soc. Trans., 16: 241.
Lieber, C. S. and DeCarli, L. M., 1968, Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding, Science, 162: 917.
Lieber, C. S. and DeCarli, L. M., 1974, An experimental model of alcohol feeding and liver injury in the baboon, J. Med. Primatol., 3: 153.
Lieber, C. S. and DeCarli, L. M., 1989, Effects of mineral and vitamin supplementation on the alcohol-induced fatty liver and microsomal induction, Alcoholism: Clin. Exp. Res., 13: 142.
Lieber, C. S. and Rubin, E., 1968, Alcoholic fatty liver in man on a high protein and low fat diet, Am. J. Med., 44: 200.
Lieber, C. S., Jones, D. P., and DeCarli, L. M., 1965, Effects of prolonged ethanol intake:production of fatty liver despite adequate diets, J. Clin. Invest., 44: 1009.
Lieber, C. S., DeCarli, L. M., Mak, K. M., Kim, C-I., and Leo, M. A., 1990, Attenuation of alcohol-induced hepatic fibrosis by polyunsaturated lecithin, Hepatology, 12: 1390.
Moshage, H., Casini, A., and Lieber, C.S., 1990, Acetaldehyde selectively stimulates collagen production in cultured rat liver fat-storing cells but not in hepatocytes, Hepatology, 12: 511.
Savolainen, E-R., Leo, M. A., Timpl, R., and Lieber, C. S., 1984, Acetaldehyde and lactate stimulate collagen synthesis of cultured baboon liver myofibroblasts, Gastroenterology 87: 777.
Summary of Vital Statistics, 1986, New York: Department of Health, City of New York, Bureau of Health Statistics and Analysis.
Weiner, F. R., Eskreis, D. S., Compton, K. V., Orrego, S., and Zern, M. A., 1988, Haplotype analysis of type I collagen gene and its association with alcoholic cirrhosis in man, Mol. Asp. Med., 10: 159.
Worner, T. M., and Lieber, C. S., 1985, Perivenular fibrosis as precursor lesion of cirrhosis, JAMA., 254: 627.
Yamada, S., Mak, K. M., and Lieber, C. S., 1985, Chronic ethanol consumption alters rat liver plasma membranes and potentiates release of alkaline phosphatase, Gastroenterology, 88: 1799.
Badawy, A.A., Morgan, CJ., Lane, J., Dhaliwal, K., and Bradley, D.M., 1989, Liver tryptophan pyrrolase: A major determinant of the lower brain 5-hydroxytryptamine concentration in alcohol-preferring C57BL mice, Biochem. J. 264: 597–599.
Cicero, TJ., 1979, A critique of animal analogues of alcoholism, in: “Biochemistry and Pharmacology of Ethanol, Vol. 2”, E. Majchrowicz and E.P. Noble, eds., Plenum Press, New York, pp. 533–560.
Cloninger, C.R., 1986, Genetics of alcoholism, Alcoholism: Clin. Exp. Res. 9: 479–482.
DeFries, J.C., Wilson, J.R., Erwin, V.G., and Petersen, D.R., 1989, LS X SS recombinant inbred strains of mice: Initial characterization, Alcoholism: Clin. Exp. Res. 13: 196–200.
Deitrich, R.A., and Melchior, C.L., 1985, A critical assessment of animal models for testing new drugs for altering ethanol intake, in: “Research Advances in New Psychopharmacological Treatments for Alcoholism”, C.A. Naranjo and E.M. Sellers, eds., Excerpta Medica, Amsterdam, pp. 23–43.
Froehlich, J.C., Harts, J., Lumeng, L, and Li, T.-K., 1988, Differences in response to the aversive properties of ethanol in rats selectively bred for oral ethanol preference, Pharmacol. Biochem. Behay. 31: 215–222.
Goldman, D., Lister, R.G., and Crabbe, J.C., 1987, Mapping of a putative genetic locus determining ethanol intake in the mouse, Brain Res. 420: 220–226.
Goldstein, D.B., and Pal, N., 1971, Alcohol dependence produced in mice by inhalation of ethanol; grading the withdrawal reaction, Science 172: 288–290.
Hansen, C., and Spuhler, K, 1984, Development of the National Institutes of Health genetically heterogeneous rat stock, Alcoholism: Clin. Exp. Res. 8: 477–479.
Hwang, B.H., Lumeng, L., Wu, J.-Y., and Li, T.-K., 1990, Increased number of GABAergic terminals in the nucleus accumbens is associated with alcohol preference in rats, Alcoholism: Clin. Exp. Res. 14: 503–507.
Korpi, E.R., Sinclair, J.D., Kaheinen, P., Viitamaa, T., Hellevuo, K., and Kiianmaa, K., 1988, Brain regional and adrenal monoamine concentrations and behavioral responses to stress in alcohol-preferring AA and alcohol-avoiding ANA rats, Alcohol 5: 417–425.
Li, T.-K., 1985, Genetic variability in response to ethanol in humans and experimental animals, in: “Proceedings: NIAAA-WHO Collaborating Center Designation Meeting and Alcohol Research Seminar”, L.H. Towle, ed., U.S. Government Printing Office, Washington, D.C., pp. 50–62.
Li, T.-K., Lumeng, L., McBride, W.J., Waller, M.B., and Hawkins, D.T., 1979, Progress toward a voluntary oral-consumption model of alcoholism, Drug and Alcohol Dependence 4: 45–60.
Lieber, C.S., 1988, Biochemical and molecular basis of alcohol-induced injury to liver and other tissues, N. Engl. J. Med. 319: 1639–1650.
Lieber, C.S., and DeCarli, L.M., 1982, The feeding of alcohol in liquid diets: Two decades of applications and 1982 update, Alcoholism: Clin. Exp. Res. 6: 523–531.
Lyon, M.F., and Searle, A.G., eds., 1989, in: “Genetic variants and strains of the laboratory mouse, 2nd Edition”, Oxford, England, Oxford University Press, New York.
McClearn, G.E., and Erwin, V.G., 1982, Mechanisms of genetic influence on alcohol-related behaviors, in: “Alcohol and Health Monograph I. Alcohol Consumption and Related Problems”, U.S. Government Printing Office, Washington, D.C., pp. 263–289.
Miller, S.S., Goldman, M.E., Erickson, C.K., and Shorey, R.L., 1980, Induction of physical dependence on and tolerance to ethanol in rats fed a new nutritionally complete and balanced liquid diet, Psychopharmacology 68: 55–59.
Murphy, J.M., Gatto, G.J., McBride, W.J., Lumeng, L., and Li, T.-K., 1989, Operant responding for oral ethanol in the alcohol-preferring P and alcohol-nonpreferring (NP) lines of rats, Alcohol 6: 127–131.
Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K., 1982, Regional brain levels of monoamines in alcohol-preferring and -nonpreferring lines of rats, Pharmacol. Biochem. Behay. 16: 145–149.
Penn, P.E., McBride, W.J., Lumeng, L., Gaff, T.M., and Li, T.-K., 1978, Neurochemical and operant behavioral studies of a strain of alcohol-preferring rats, Pharmacol. Biochem. Behay. 8: 475–481.
Randall, C.L., 1987, Alcohol as a teratogen, Alcohol and Alcoholism, 1: 125–132.
Sorensen, S., Palmer, M., Dunwiddie, T.V., and Hoffer, B.M., 1980, Electrophysiological correlates of ethanol-induced sedation in differentially sensitive lines of mice, Science 210: 1143–1145.
Tsukamoto, H., French, S.W., Benson, N., Delgado, G., Rao, G.A., Larkin, E.C., and Largman, C., 1985, Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet, Hepatology 5: 224–232.
Wafford, K.A., Burnett, D.M., Dunwiddie, T.V., and Harris, R.A., 1990, Genetic differences in the ethanol sensitivity of GABAA receptors expressed in Xenopus oocytes, Science 249: 291–293.
Walker, D.W., Hunter, B.E., and Abraham, W.C., 1981, Neuroanatomical and functional deficits subsequent to chronic ethanol administration in animals, Alcoholism: Clin. Exp. Res. 5: 267–282.
Waller, M.B., McBride, WJ., Gatto, G.J., Lumeng, L., and Li, T.-K., 1984, Intragastric self-infusion of ethanol by the P and the NP (alcohol-preferring and -nonpreferring) lines of rats, Science 225: 78–80.
Waller, M.B., McBride, WJ., Lumeng, L., and Li, T.-K., 1982, Induction of dependence on ethanol by free-choice drinking in alcohol-preferring rats, Pharmacol. Biochem. Behay. 16: 501–507.
Wong, D.T., Lumeng, L., Threlkeld, P.G., Reid, L.R., and Li, T.-K., 1988, Serotonergic and adrenergic receptors of alcohol preferring and non-preferring rats, J. of Neural Transm. 71: 207–218.
Lieber, C.S., Seitz, H.K., Garro, A.J. and Worner, T.M. (1979) Alcohol and cancer. Cancer Res 39: 2863–2886.
Maier, H., Dietz, A., Zielinski, D., Junemann, K.H. and Heller, W.D., 1990, Risikofaktoren bei Plattenepithelkarzinomen der Mundhohle, des Oropharynx, des Hypopharynx und des Larynx. Deutsch Med Wschr 115: 843–850.
Rothman, E. and Keller, A.Z., 1972, The effect of joint exposure to alcohol and tobacco on risk of cancer of the mouth and pharynx J Chron Dis 25: 711–716.
Sandblad, B. and Meinzer, H.P., 1991, Modelling of complex control structures in biology and biomedicine. Meth Inf Med.
Seitz, H.K.and Simanowski, U.A., 1986, Ethanol and carcinogenesis of the alimentary tract. Alcoholism Clin Exp Res 10: 33S - 40S.
Seitz, H.K.and Simanowski, U.A., 1988, Alcohol and carcinogenesis. Ann Rev Nutr 8: 99–119.
Wright, N.A.and Alison, M., 1984, The biology of epithelial cell populations. Clarendon,Oxford.
Bleuler, E., 1981 Lehrbuch der Psychiatrie, Berlin.
Conley, J.J. and Prioleau, L.A., 1983, Personality typology of men and women alcoholics in relation to etiology and prognosis. J. Stud. Alc., 44: 996.
Dahlgren, K.G., 1975, Special problems in female alcoholism. Brit.J.Add. 70: 18.
Gomberg, E.S., 1974, Women and alcoholism. In: V. Franks, V. Burtle, eds., “Women in therapy”. Brunner/Mazel New York; 169.
Guillespie, D.G., 1967, The fate of alcoholics: An evaluation of alcoholism follow-up studies. In: D.J. Pittman (Ed.) alcoholism. Harper and Row, New York.
Harford, T.C. and Mills, G.S., 1978, Age-related trends in alcohol consumption. J.Stud.Alc. 39: 207.
Hoff, H., 1956, Lehrbuch der Psychiatrie, Verhütung Prognostik und Behandlung der geistigen und seelischen Erkrankungen, Basel, Stuttgart.
Koehler, K. and Sass, H., 1984, Diagnostisches und Statistisches Manual Psychischer Störungen, DMS-III. Beltz, Weinheim.
Lesch, O.M., 1985, Chronischer Alkoholismus. Typen und ihr Verlauf. Eine Langzeitstudie. Thieme Verlag.
Lesch, O.M., Kefe, J., Lentner, S., Mader, R., Marx, B., Musalek, M., Nimmerrichter, A., Presinsberger, H., Puchinger, H., Rustembegovic, A., Walter, H., 1990, Diagnosis of Chronic Alcoholism - Classificatory Problems. Psychopathology 23: 88.
Raunsville, B.J., Dolinsky, Z.S., Babor, T.F. and Meyer, R.E., 1987, Psychopathology as a Predictor of Treatment Outcome in Alcoholics. Archs Psychiat. 44: 505.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Plenum Press, New York
About this chapter
Cite this chapter
von Wartburg, JP., Lieber, C.S., Li, TK., Israel, Y., Seitz, H.K., Lesch, O.M. (1991). Future Directions in Biomedical Research on Alcoholism. In: Palmer, T.N. (eds) Alcoholism. NATO ASI Series, vol 206. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5946-3_34
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5946-3_34
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5948-7
Online ISBN: 978-1-4684-5946-3
eBook Packages: Springer Book Archive