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Mechanisms of Lymphocyte Activation and Immune Regulation III pp 215–226Cite as

Differences in Human B Cell Differentiation

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 292))

Abstract

A comparative approach to the study of immune system development has been extremely useful in our understanding of this complex process. For example, it was first experimentally demonstrated in chickens that the immune system had two antigen specific components, T and B cells. This dichotomy was subsequently found to exist in organisms as diverse as humans and frogs.1,2 Extrapolation of many findings in mammalian B cell differentiation can often be readily made between humans and mice. However, we will discuss several instances where models of B cell development that have been derived from murine systems do not appear to be directly applicable to humans. In some cases the apparent differences may simply be due to the experimental systems employed, but in others there may be fundamental differences between the two species. Since our purpose is not to minimize the value of comparative analysis, recent data concerning early B cell development in humans that most likely is true in mice will also be discussed.

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Authors and Affiliations

  1. Division of Developmental and Clinical Immunology, Departments of Pediatrics, Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA

    Peter D. Burrows, Hiromi Kubagawa, Norihiro Nishimoto & Max D. Cooper

  2. The Howard Hughes Medical Institute, Birmingham, Alabama, USA

    Max D. Cooper

  3. Department of Genetics, Stanford University School of Medicine, Stanford, California, USA

    William G. Kerr

  4. Department of Tumor Cell Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

    Gary V. Borzillo & Linda M. Hendershot

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  1. Peter D. Burrows
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  2. Hiromi Kubagawa
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  3. Norihiro Nishimoto
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  4. William G. Kerr
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  5. Gary V. Borzillo
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  6. Linda M. Hendershot
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  7. Max D. Cooper
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Editor information

Editors and Affiliations

  1. Department of Medicine, University of California, Irvine, California, 92717, USA

    Sudhir Gupta

  2. Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA

    William E. Paul

  3. The Howard Hughes Medical Institute, University of Alabama, Birmingham, Alabama, 35294, USA

    Max D. Cooper

  4. Department of Biology, California Institute of Technology, Pasadena, California, 91125, USA

    Ellen V. Rothenberg

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© 1991 Plenum Press, New York

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Burrows, P.D. et al. (1991). Differences in Human B Cell Differentiation. In: Gupta, S., Paul, W.E., Cooper, M.D., Rothenberg, E.V. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation III. Advances in Experimental Medicine and Biology, vol 292. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5943-2_24

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  • DOI: https://doi.org/10.1007/978-1-4684-5943-2_24

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