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Cells Inducing Tolerance to Mls and H-2 Antigens

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Mechanisms of Lymphocyte Activation and Immune Regulation III

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 292))

Abstract

The thymus shapes the T cell repertoire by selecting T cells which recognize foreign antigens in association with self major histocompatibility complex (MHC) molecules and by tolerizing those cells which have the potential to react to self antigens.1,2 There is now convincing evidence that negative selection (tolerance induction) of potentially self-reactive cells can occur by a process of clonal deletion.3-5 Direct support for this viewpoint has come from studies with monoclonal antibodies (mAB) specific for particular T cell receptor (TCR) Vβ gene products. Thus, it has been found that mature T cells bearing Vβ11, Vβ17, and Vβ5-positive TCRs are selectively deleted in I-E-positive mouse strains, presumably because these TCRs have high reactivity for I-E molecules (perhaps complexed with self peptides).6–8 Similar results are found for Mls antigens, a set of poorly characterized self antigens which have the unusual property of stimulating very high primary mixed lymphocyte responses (MLR).9,10 Thus, Mlsa-positive mouse strains delete Vβ6 and Vβ8.1-positive T cells and Mlsc-positive strains delete T cells bearing Vβ3.11–14

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Authors and Affiliations

  1. Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California, USA

    Susan R. Webb & Jonathan Sprent

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  1. Susan R. Webb
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  2. Jonathan Sprent
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Editors and Affiliations

  1. Department of Medicine, University of California, Irvine, California, 92717, USA

    Sudhir Gupta

  2. Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA

    William E. Paul

  3. The Howard Hughes Medical Institute, University of Alabama, Birmingham, Alabama, 35294, USA

    Max D. Cooper

  4. Department of Biology, California Institute of Technology, Pasadena, California, 91125, USA

    Ellen V. Rothenberg

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© 1991 Plenum Press, New York

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Webb, S.R., Sprent, J. (1991). Cells Inducing Tolerance to Mls and H-2 Antigens. In: Gupta, S., Paul, W.E., Cooper, M.D., Rothenberg, E.V. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation III. Advances in Experimental Medicine and Biology, vol 292. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5943-2_17

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  • DOI: https://doi.org/10.1007/978-1-4684-5943-2_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5945-6

  • Online ISBN: 978-1-4684-5943-2

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