Abstract
Chloride channels are present in plasma membranes and in intracellular organelles. In a variety of epithelial cells these channels mediate NaCl absorption and secretion. The aim of our work was to purify the Cl channel and to develop molecular reagents that could be used to study the biochemical basis of cystic fibrosis.
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References
D.W. Landry, M. Reitman, E.J. Cragoe and Q. Al-Awqati, 1987, Epithelial Chloride Channels; Development of inhibitory ligands, J. Gen. Physiol., 90:779.
D.W. Landry, M.H. Akabas, C.Redhead, A. Edelman, E.J. Cragoe, Jr., and Q. Al-Awqati, 1989, Purification and reconstitution of chloride channels from kidney and trachea, Scien ce, 244:1469.69.
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© 1991 Springer Science+Business Media New York
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Al-Awqati, Q., Landry, D., Akabas, M., Redhead, C., Edelman, A., Edwards, J. (1991). Purification of the Epithelial Cl Channel. In: Tsui, LC., Romeo, G., Greger, R., Gorini, S. (eds) The Identification of the CF (Cystic Fibrosis) Gene. Advances in Experimental Medicine and Biology, vol 290. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5934-0_23
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DOI: https://doi.org/10.1007/978-1-4684-5934-0_23
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