Abstract
A system influencing the availability of energy to the entire organism, expectedly, depends on a widespread network directed by the central nervous system. Indeed, there are complex interactions between “controllers” in the brain and peripheral mechanisms for energy consumption and release, as well as the complex machinery mediating chemical energy storage (predominantly as triglyceride) and mobilization. Critical afferent and efferent systems connect the hypothalamic and other brain centres which control food intake and energy disposal, with the relevant target sites. This brief review will summarize four mechanisms whereby the brain, particularly the hypothalamus along with its interconnecting neural structures, can influence body fat content.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
G. A. Bray, D. A. York, and J. S. Fisler, Experimental obesity: A homeostatic failure due to defective nutrient stimulation of the sympathetic nervous system, Vitamins and Hormones 45:1 (1989),
G. A. Bray, J. Fisler, and D. A. York, Neuroendocrine control of the development of obesity: Understanding gained from studies of experimental animal models, Frontiers in Neuroendocrinology 11:0 (1990).
G. J. Taborsky, Jr. This issue.
D. A. K. Roncari, Obesity and lipid metabolism, in Clinical Medicine, J. A. Spittell, Jr., ed., Harper & Rowe, Philadelphia (1986).
J. E. Morley, Neuropeptide regulation of appetite and weight, Endocr. Rev. 8:256 (1987).
A. S. Levine, B. Rogers, J. Kneip, M. Grace, and J. E. Morley, Effect of centrally administered corticotropin-releasing factor (CRF) on multiple feeding paradigms, Neuropharmacol. 22:337 (1983).
K. Hanai, Y. Oomura, Y. Kai, K. Nishikawa, N. Shimizu, H. Morita, and C. R. Plata-Salaman, Central action of acidic fibroblast growth factor in feeding regulation, Am. J. Physiol. 256:R217 (1989).
C. R. Plata-Salaman, Y. Oomura, and Y. Kai, Tumor necrosis factor and interleukin-Iß: suppression of food intake by direct action in the central nervous system, Brain Res. 448:106 (1988).
D. A. K. Roncari and P. E. Le Blanc, Inhibition of rat perirenal preadipocyte differentiation, Biochem. Cell Biol. 68:238 (1990).
D. C. W. Lau, D. A. K. Roncari, D. K. Yip, S. Kindler, and S. G. E. Nilsen, Purification of a pituitary polypeptide that stimulates the replication of adipocyte precursors in culture. FEBS Lett. 153:395 (1983).
D. A. K. Roncari, Pre-adipose cell replication and differentiation, Trends Biochem. Sci. 9:486 (1984).
D. C. W. Lau, D. A. K. Roncari, and C. H. Hollenberg, Release of mitogenic factors by cultured preadipocytes from massively obese human subjects, J. Clin. Invest. 79:632 (1987).
J. E. Morley, Appetite regulation by gut peptides, Annu. Rev. Nutr. 10:383 (1990).
D. A. K. Roncari, Obesity and lipid metabolism, in Systematic Endocrinology, C. Ezrin, J. O. Godden, and R. Volpe, eds., Harper and Rowe, Hagerstown (1979).
D. A. K. Roncari, Hormonal influences on the replication and maturation of adipocyte precursors, Int. J. Obes. 5:547 (1981) .
C. H. Hollenberg and A. Vost, Regulation of DNA synthesis in fat cells and stromal elements from rat adipose tissue, J. Clin. Invest. 47:2485 (1968).
M. Morikawa, T. Nixon, and H. Green, Growth hormone and the adipose conversion of 3T3 cells, Cell 29:783 (1982).
K. M. Zezulak and H. Green, The generation of insulin-growth factor-I sensitive cells by growth hormone action, Science 233:551 (1986).
D. A. K. Roncari, Individual variations in energy utilized for biomechanical processes and molecular mobility account for diverse susceptibility to obesity, Medical Hypotheses 23:11 (1987).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Plenum Press, New York
About this chapter
Cite this chapter
Roncari, D.A.K. (1991). Relationships Between the Hypothalamus and Adipose Tissue Mass. In: Vranic, M., Efendic, S., Hollenberg, C.H. (eds) Fuel Homeostasis and the Nervous System. Advances in Experimental Medicine and Biology, vol 291. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5931-9_9
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5931-9_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5933-3
Online ISBN: 978-1-4684-5931-9
eBook Packages: Springer Book Archive