Abstract
The average normal, human male brain represents approximately 2% of total body weight but consumes about 20% of the total body basal oxygen consumption (Sokoloff, 1989). The substrate for this high rate of energy metabolism is normally almost exclusively glucose (TABLE 1) (Sokoloff, 1960). In fact, more glucose is consumed than can be oxidized completely to carbon dioxide and water by the oxygen consumption, indicating that the glycolytic rate exceeds the rate of oxidation of the products of glycolysis, normally by about 20% (Table 1). The excess carbon derived from glycolytic utilization of glucose is probably distributed in many, e.g., lactate, pyruvate, and other intermediates of the glycolytic and tricarboxylic acid cycle pathways that leave the brain in amounts too insignificant to be detected in the cerebral blood, and also into several neurotransmitter pools, such as acetylcholine, glutamate, GABA, etc.
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© 1991 Plenum Press, New York
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Sokoloff, L. (1991). Measurement of Local Cerebral Glucose Utilization and its Relation to Local Functional Activity in the Brain. In: Vranic, M., Efendic, S., Hollenberg, C.H. (eds) Fuel Homeostasis and the Nervous System. Advances in Experimental Medicine and Biology, vol 291. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5931-9_4
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DOI: https://doi.org/10.1007/978-1-4684-5931-9_4
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