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Ribonuclease H and Primer tRNA Binding Activities of HIV Reverse Transcriptase as Therapeutic Targets

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Advances in Molecular Biology and Targeted Treatment for AIDS

Abstract

Human immunodeficiency virus reverse transcriptase (RT, deoxynucleoside-triphosphate: DNA deoxynucleotidyltransferase (RNA-directed), E.C. 2.7.7.49.) has been the subject of intense investigation over the last 5 years, with the goal of developing a safe and effective therapy to stem the progression of AIDS. Although success has been achieved with inhibitors of viral replication such as AZT1–3, the rapid emergence of tolerance to this drug4 is a clear indication that new and improved therapies will be in constant demand for a considerable period.

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Author information

Authors and Affiliations

  1. Div. of Infectious Diseases, CWRU School of Medicine, Cleveland, OH, 44106, USA

    Stuart F. J. Le Grice

  2. ZFE/Bio, Hoffmann-La Roche Ltd., Basel, Switzerland

    Oktavian Schatz

  3. Labo-retro, CRBCG du CNRS, F-31062, Toulouse, France

    Jean-Luc Darlix

Authors
  1. Stuart F. J. Le Grice
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  2. Oktavian Schatz
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  3. Jean-Luc Darlix
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Editor information

Editors and Affiliations

  1. The George Washington University Medical Center, Washington, D.C., USA

    Ajit Kumar

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© 1991 Plenum Press, New York

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Le Grice, S.F.J., Schatz, O., Darlix, JL. (1991). Ribonuclease H and Primer tRNA Binding Activities of HIV Reverse Transcriptase as Therapeutic Targets. In: Kumar, A. (eds) Advances in Molecular Biology and Targeted Treatment for AIDS. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5928-9_6

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  • DOI: https://doi.org/10.1007/978-1-4684-5928-9_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5930-2

  • Online ISBN: 978-1-4684-5928-9

  • eBook Packages: Springer Book Archive

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